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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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William J. Craigen, M.D., Ph.D.

William J. Craigen

Professor
Department of Molecular and Human Genetics
Department of Pediatrics - Molecular and Human Genetics
Medical Director of Mitochondrial Laboratory

Phone: 713-798-8305
Fax: 713-798-7773
E-mail: wcraigen@bcm.edu

Education

  • M.D., Ph.D., Baylor College of Medicine, Houston, TX
  • Fellowship, Medical Genetics, Baylor College of Medicine, Houston, TX
  • Residency, Pediatrics, Baylor College of Medicine, Houston, TX

Research Interests

  • Energy metabolism
  • Mitochondrial function
  • Transgenic models

Clinical Focus

  • Human genetic diseases
  • Inborn errors of metabolism
  • Mitochondrial diseases

Selected Publications

  • Anflous-Pharayra K, Cai ZJ, Craigen WJ. VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles. Biochim Biophys Acta. 2007. 1767:136-42.
  • Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol. 2007. 9:550-5.
  • Sabirov RZ, Sheiko T, Liu H, Deng D, Okada Y, Craigen WJ. Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. J Biol Chem. 2006. 281:1897-1904.
  • Graham BH, Craigen W. Mitochondrial voltage-dependent anion channel gene family in Drosophila melanogaster: Complex patterns of evolution, genomic organization, and developmental expression. Mol Gene Metab. 2005. 85:308-17.
  • Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ. VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science. 2003. 301:513-7.
  • Sutton VR, Pan Y, Davis EC, Craigen WJ. A mouse model of argininosuccinic aciduria: Biochemical characterization. Mol Gene Metab. 2003. 78:11-6.
  • Weeber EJ, Levy M, Sampson MJ, Anflous K, Armstrong D, Brown SE, Sweatt JD, Craigen WJ. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. J Biol Chem. 2002. 277:18891-7.

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