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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Lawrence C. B. Chan, M.B., D.Sc.

Lawrence C. B. Chan

Professor and Chief
Department of Medicine - Diabetes, Endocrinology
and Metabolism

Phone: 713-798-4788
Fax: 713-798-8764


  • M.B., D.Sc., University of Hong Kong
  • Postdoctoral, Washington University, St. Louis, MO

    Research Interests

  • Molecular mechanisms of dyslipidemia and diabetes
  • RNA editing
  • Apolipoproteins
  • Atherosclerosis

Selected Publications

  • Chang BH, Chan L. Emerging role of lipid droplet protein ADFP in health and disease. Am J Physiol Gastroinest Liver Physiol. 2007. 292:G1465-8.
  • Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L. Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes. Proc Natl Acad Sci U S A. 2007. 104:4030-5.
  • Oka K, Belalcazar LM, Dieker C, Nour EA, Nuno-Gonzalez P, Paul A, Cormier S, Shin J-K, Finegold M, Chan L. Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. Gene Therapy. 2007. 14:191-202.
  • Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation. 2007. 115:1408-16.
  • Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 2007. 115:1029-38.
  • Chang BH-J, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, Chan L. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation related protein (ADFP). Mol Cell Biol. 2006. 26:1063-76.
  • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Inves. 2006. 116:1102-9.

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