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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Malcolm K. Brenner, M.D., Ph.D.

Malcolm K. Brenner

Department of Medicine - Hematology and Oncology
Department of Pediatrics - Hematology and Oncology
Director of Center for Cell and Gene Therapy

Phone: 832-824-4671
Fax: 832-825-4688


  • M.B.Ch.B. (M.D.), University of Cambridge
  • Ph.D., University of Cambridge
  • Medicine Fellowship, Royal College of Physicians
  • Hematology Fellowship, Royal College of Pathologists

Research Interests

  • Cell and gene therapy of cancer

Clinical Focus

  • Stem cell transplant
  • Immunotherapies
  • Hematological malignancies

Selected Publications

  • Kamble RT, Clark DA, Leong HN, Heslop HE, Brenner MK, Carrum G. Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007. 40(6):563-6.
  • Olmsted-Davis E, Gannon FH, Ozen M, Ittman MM, Gugala Z, Hipp JA, Moran KM, Fouletier-Dilling CM, Schumara-Martin S, Lindsey RW, Heggeness MH, Brenner MK, Davis AR. Hypoxic adipocytes pattern early heterotopic bone formation. Am J Pathol. 2007. 170:620-32.
  • Savoldo B, Rooney CM, Di Stasi A, Abken H, Hombach A, Foster AE, Zhang L, Heslop HE, Brenner MK, Dotti G. Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood. 2007. 110(7):2620-30.
  • Tey SK, Dotti G, Rooney CM, Heslop HE, Brenner MK. Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol Blood Marrow Transplant. 2007. 13:913-24.
  • Vu T, Carrum G, Hutton G, Heslop HE, Brenner MK, Kamble R. Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007. 39(11):705-9.
  • Wang H, Yang G, Timme TL, Fujita T, Naruishi K, Frolov A, Brenner MK, Kadmon D, Thompson TC. IL-12 gene-modified bone marrow cell therapy suppresses the development of experimental metastatic prostate cancer. Cancer Gene Ther. 2007. 14(10):819-27.
  • Kennedy-Nasser AA, Leung KS, Mahajan A, Weiss HL, Arce JA, Gottschalk S, Carrum G, Khan SP, Heslop HE, Brenner MK, Bollard CM, Krance RA. Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia. Biol Blood Marrow Transplant. 2006. 12:1277-84.

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