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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Donald Shaffer, Ph.D.

Donald Shaffer

Department of Pediatrics-Hematology and Oncology

Thesis Title: Adoptive Immunotherapy for CD70-Positive Malignancies Using Genetically Modified T Cells

Basic Science Mentor: Cliona Rooney, Ph.D.
Department of Pediatrics-Hematology and Oncology

Clinical Science Mentor: Stephen Gottschalk, M.D.
Department of Pediatrics-Hematology and Oncology

Education:
Ph.D., Translational Biology and Molecular Medicine, Baylor College of Medicine, 2010
M.S., Biology/ Biochemistry, Northern Michigan University
B.S., Physiology, Northern Michigan University

Position after graduation: Postdoctoral fellowship in the lab of Dr. Kai Wucherpfennig, Dana Farber Cancer Institute, Boston, MA.

Awards and Honors

  • $20,000 grant from the Bear Necessities Pediatric Tumor Foundation, 2010 (photo)
  • Third Place Poster Presentation, TXCCC Research Symposium, Baylor College of Medicine, 2010
  • First Place Oral Presentation, TBMM Research Conference, Baylor College of Medicine, 2009
  • Graduate Student Teaching Award, CAGT Retreat, Baylor College of Medicine, 2008
  • Second Place Oral Presentation, CAGT Retreat, Baylor College of Medicine, 2008
  • ASBMT Travel Award to Annual Meeting, San Diego, Calif., 2008
  • First Place Abstract/Poster in Basic Sciences, DLDCC, Baylor College of Medicine, 2007
  • First Place TBMM Talk-Off, Baylor College of Medicine, 2007
  • Third Place Poster Prize, CAGT Retreat, Baylor College of Medicine, 2006
  • Cell and Gene Therapy Training Grant (T32), Baylor College of Medicine, 2006
  • Excellence in Education Award, NMU, 2003
  • Charles C. Spooner Grant, NMU, 2002

Publications

  • Shaffer DR, Savoldo B, Yi Z, Chow KH, Spencer D, Dotti G, Wu M, Liu H, Kenney S, Gottschalk S. T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. Blood. Submitted April 2010.
  • Shaffer DR, Rooney CM, Gottschalk S. Immunotherapeutic options for Epstein-Barr virus-associated lymphoproliferative disease following transplantation. Immunotherapy. In press 2010.
  • Ahmed N, Salsman VS, Kew Y, Shaffer D, Powell S, Zhang YJ, Grossman RG, Heslop HE, Gottschalk S. HER2-specific T cells target primary Glioblastoma stem cells and induce regression of autologous experimental tumors. Clin Cancer Res. 2010. 16(2), 474-85.
  • Hartmaier RJ, Shaffer DR. Graduate students bring clinical know-how into their lab work through the HHMI Med into Grad program. Dis Model Mech. 2009. 2(11-12), 531-2 .
  • Kaka AS, Shaffer DR, Hartmaier R, Leen AM, Lu An, Bear A, Rooney CM, Foster AE. Genetic Modification of T Cells with IL-21 Enhances Antigen Presentation and Generation of Central Memory Tumor-Specific Cytotoxic T Lymphocytes. J Immunother. 2009. 32(7). 726-36.

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