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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Xiang Zhang, Ph.D.

Xiang Zhang, Ph.D.Assistant Professor
Lester and Sue Smith Breast Center
Department of Molecular and Cellular Biology

Phone: 713-798-6239


  • Ph.D., Columbia University, New York, NY
  • Postdoctoral training, Memorial Sloan Kettering Cancer Center, New York, NY

Research Interests

  • Molecular and cellular mechanisms underlying breast cancer metastasis
  • Therapeutic strategies targeting micrometastases
  • Genomic and epigenomic alterations during metastasis progression

Selected Publications

  • Zhang XH, Jin X, Massagué J. Metastasis seed pre-selection by the primary tumour stroma. (In revision)
  • Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell. 2009 Jul 10;138(1):51-62.
  • Zhang XH*, Wang Q*, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massagué J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell. 2009 Jul 7;16(1):67-78. (*indicates equal first-authorship)
  • Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J. Genes that mediate breast cancer metastasis to the brain. Nature. 2009 Jun 18;459(7249):1005-9.
  • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massagué J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008 Apr 4;133(1):66-77.
  • Zhang XH, Chasin LA. Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13427-32.
  • Zhang XH, Chasin LA. Computational definition of sequence motifs governing constitutive exon splicing. Genes Dev. 2004 Jun 1;18(11):1241-50.

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