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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Yong Xu, M.D., Ph.D.

Yong Xu, M.D., Ph.D.Assistant Professor
Department of Pediatrics-Nutrition

Phone: 713-798-7199
Fax: 713-798-7187
E-mail: yongx@bcm.edu

Education

  • M.D., Tongji Medical University, Wuhan, Hubei, China
  • Ph.D., University of Alberta, Edmonton, Alberta, Canada
  • Postdoctoral Fellow, The University of Texas Southwestern Medical Center, Dallas, TX

Research Interests

  • To identify neural networks that mediate effects of estrogen on energy and glucose homeostasis
  • To identify neural networks that mediate effects of 5-HT on energy and glucose homeostasis
  • To unravel the CNS mechanisms underlying stress-induced hypertension

Selected Publications

  • Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK and Clegg DJ. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. 2011. Cell Metabolism (in press).
  • Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK.Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 2011 Aug 11;71(3):488-97.
  • Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec;13(12):1457-9.
  • Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci. 2010 Nov 3;30(44):14630-4.
  • Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 4;12(1):88-95.
  • Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26;60(4):582-9.
  • Xu Y, Krukoff TL. Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A. Br J Pharmacol. 2006 May;148(1):70-7.

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