Laising Yen, Ph.D.
Department of Pathology and Immunology
Department of Molecular and Cellular Biology
Lab Web Site: Yen Lab
- Ph.D., Yale University, New Haven
- Postdoctoral, Yale University, School of Medicine, New Haven
- Postdoctoral, Harvard Medical School, Children's Hospital, Boston
- Investigating the roles of mutational event in cancer transcriptome, including chimeric RNA, alternative splicing, alternative polyadenylation, and RNA editing.
- Identifying secreted proteins in cancer for early detection.
- Developing RNA-based switches for gene regulation applications in gene/cell therapy.
- Kannan K, Wang L, Wang J, Ittmann MM, Li W, Yen L. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9172-7.
- Wang L, Xi Y, Yu J, Dong L, Yen L, Li W. A statistical method for the detection of alternative splicing using RNA-seq. PLoS One. 2010 Jan 8;5(1):e8529.
- Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods Mol Biol. 2009;540:335-47.
- Link KH, Guo L, Ames TD, Yen L, Mulligan RC, Breaker RR. Engineering high-speed allosteric hammerhead ribozymes. Biol Chem. 2007 Aug;388(8):779-86.
- Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006 May;12(5):797-806.
- Yen L, Svendsen J, Lee JS, Gray JT, Magnier M, Baba T, D'Amato RJ, Mulligan RC. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature. 2004 Sep 23;431(7007):471-6.
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