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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Christine Beeton, Ph.D.

Christine Beeton, Ph.D.Assistant Professor
Department of Molecular Physiology and Biophysics

Phone: 713-798-5030
E-mail: beeton@bcm.edu
Lab: Beeton Lab

Education

  • Ph.D., Immunology, Faculté des Sciences de Luminy, Marseilles, France
  • Postdoctoral, University of California, Irvine

Research Interests

  • Chronic inflammatory diseases (multiple sclerosis, rheumatoid arthritis, asthma)
  • Potassium channels
  • Development of selection ion channel modulators

Selected Publications

  • Beeton C, Pennington MW, Norton RS. Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases. Inflamm Allergy Drug Targets. 2011 Aug 8. [Epub ahead of print]
  • Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, et al. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr;75(4):762-73.
  • Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17;29(4):602-14.
  • Beeton C, Garcia A, Chandy KG. Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis. J Vis Exp. 2007;(5):224.
  • Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9.
  • Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, et al. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13942-7.

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