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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Stephen C. Pflugfelder, M.D.

Stephen C. Pflugfelder

Professor
Department of Ophthalmology

Phone: 713-798-4732
E-mail: stevenp@bcm.edu

Education

  • M.D., SUNY-Upstate Medical College, Syracuse, NY
  • Internship, Presbyterian University of Pennsylvania Medical Center, Philadelphia, PA
  • Residency, Ophthalmology, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX
  • Fellowship, Cornea and External Disease, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL

Research Interests

  • Mucosal inflammation
  • Dry eye
  • Corneal epithelial stem cell biology

Clinical Focus

  • Dry eye and ocular surface disease
  • Corneal epithelial stem cell transplantation
  • Corneal transplantation

Selected Publications

  • De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li DQ, Pflugfelder SC. Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2010 Dec 22. [Epub ahead of print]
  • Rahimy E, Pitcher JD 3rd, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug;177(2):744-53.
  • Stern ME, Schaumburg CS, Dana R, Calonge M, Niederkorn JY, Pflugfelder SC.Autoimmunity at the ocular surface: pathogenesis and regulation. Mucosal Immunol. 2010 Sep;3(5):425-42.
  • Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3083-91.
  • Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3203-9.
  • De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec;127(12):1625-31.

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