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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Li Xin, Ph.D.

Li Xin, Ph.D.Assistant Professor
Department of Molecular and Cellular Biology

Phone: 713-798-1650
Fax: 713-790-1275
E-mail: xin@bcm.edu

Education

  • Ph.D., Shanghai Institute of Biochemistry and Cell Biology, Shanghai, PRC

Research Interests

  • Cells of origin for prostate cancer
  • Prostate stem cells and prostate development
  • Molecular signaling of prostate carcinogenesis

Clinical Focus

  • Detection of malignant prostate cancer
  • Castration-resistant prostate cancer

Selected Publications

  • Zhang L, Zhang B, Valdez JM, Wang F, Ittmann M, Xin L. Dicer ablation impairs prostate stem cell activity and causes prostate atrophy. Stem Cells. 2010 Jul;28(7):1260-9.
  • Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L. Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells. Prostate. 2010 Feb 15;70(3):297-304.
  • Mulholland DJ, Xin L, Morim A, Lawson D, Witte O, Wu H. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 2009 Nov 15;69(22):8555-62.
  • Memarzadeh S, Xin L, Mulholland DJ, Mansukhani A, Wu H, Teitell MA, Witte ON. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 2007 Dec;12(6):572-85.
  • Xin L, Lukacs RU, Lawson DA, Cheng D, Witte ON. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007 Nov;25(11):2760-9.
  • Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7789-94.
  • Xin L, Lawson DA, Witte ON. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6942-7.

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