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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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K. Vinod Vijayan, Ph.D.

K. Vinod Vijayan, Ph.D.Assistant Professor
Department of Medicine - Thrombosis Research

Phone: 713-798-8677
Fax: 713-798-3415
E-mail: vvijayan@bcm.edu

Education

  • Ph.D., Cancer Research Institute, Mumbai, India
  • Postdoctoral, Johns Hopkins School of Medicine

Research Interests

  • Platelets and endothelial cells
  • Thrombosis and inflammation
  • Phosphatases

Clinical Focus

  • Drug induced thrombotic microangiopathies

Selected Publications

  • Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA. Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. J Biol Chem. 2010. 285(30):22831-9.
  • Pradhan S, Alrehani N, Patel V, Khatlani TS, Vijayan KV. Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin {alpha}IIb{beta}3 to fibrinogen. J Biol Chem. 2010 Jul 8. [Epub ahead of print]
  • Bynagari YS, Nagy B Jr, Tuluc F, Bhavaraju K, Kim S, Vijayan KV, Kunapuli SP. Mechanism of activation and functional role of protein kinase Ceta in human platelets. J Biol Chem. 2009. 284(20):13413-21.
  • Nolasco LH, Gushiken FC, Turner NA, Khatlani TS, Pradhan S, Dong JF, Moake JL, Vijayan KV. Protein phosphatase 2B inhibition promotes the secretion of von Willebrand factor from endothelial cells. J Thromb Haemost. 2009. 7(6):1009-18.
  • Gushiken FC, Patel V, Liu Y, Pradhan S, Bergeron AL, Peng Y, Vijayan KV. Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling. J Biol Chem. 2008. 283(19):12862-9.
  • Vijayan KV, Liu Y, Sun W, Ito M, Bray PF. The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases. J Biol Chem. 2005. 280(23):21756-62.
  • Vijayan KV, Liu Y, Li TT, Bray PF. Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling. J Biol Chem. 2004. 279(32):33039-42.

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