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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Sundararajah Thevananther, Ph.D.

Sudararajah Thevananther, Ph.D.Associate Professor
Department of Pediatrics - Gastroenterology, Hepatology and Nutrition

Phone: 832-824-3753
Fax: 832-825-4893


  • Ph.D., Bowling Green State University
  • Postdoctoral Research, Yale University School of Medicine

Research Interests

  • Liver regeneration
  • Fatty liver disease
  • Hepatocellular carcinoma

Selected Publications

  • Desai MS, Shabier Z, Taylor M, Lam F, Thevananther S, Kosters A, Karpen SJ. Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis. Hepatology. 2010. 51(6):2097-107.
  • Kosters A, White DD, Sun H, Thevananther S, Karpen SJ. Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha. J Hepatol. 2009. 51(5):898-908.
  • Ghose R, Mulder J, von Furstenberg RJ, Thevananther S, Kuipers F, Karpen SJ. Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver. J Hepatol. 2007. 46(1):115-23.
  • Thevananther S, Karpen SJ. Molecular Biology of the Liver Cell. In: Rodés J, Benhamou JP, Blei A, Reichen J, Rizzetto M, Dufour JF, Friedman S, Ginès P, Valla DC, Zoulim F, eds. Textbook of Hepatology: From Basic Science to Clinical Practice, 3rd edition. Blackwell Publishing, pp. 101-9, 2007.
  • Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem. 2006. 281(22):15434-40.
  • Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept. 2004. 2(1):4.
  • Thevananther S, Karpen SJ. Calcium is good for the nucleus. J Hepatol. 2004. 40(4):720-2.
  • Thevananther S, Sun H, Li D, Arjunan V, Awad SS, Wyllie S, Zimmerman TL, Goss JA, Karpen SJ. Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes. Hepatology. 2004. 39(2):393-402.

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