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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Hoang Nguyen, Ph.D.

Hoang Nguyen, Ph.D.Assistant Professor
Department of Molecular and Cellular Biology
Department of Dermatology
Center for Stem Cell and Regenerative Medicine
Cell and Gene Therapy Center

Phone: 713-798-1236
Fax: 713-798-1230


  • Ph.D., Weil Medical College of Cornell University/Sloan-Kettering Institute, New York, NY
  • Postdoctoral Fellow, Rockefeller University, New York, NY

Research Interests

  • Molecular mechanisms of self-renewal and differentiation of epithelial stem cells
  • Regulation of skin epithelial stem cells during wound repair
  • Alteration of stem cell genes during aging and tumorigenesis

Clinical Focus

  • Manipulating stem cells for maintaining the self-renewal capacity of skin stem cells in vitro for potential use in regenerative medicine
  • Wound healing/repair
  • Skin cancer

Selected Publications

  • Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E. Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet. 2009. 41(10):1068-75.
  • Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD. The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. Mol Cell Biol. 2006. 26(8):3114-23.
  • Nguyen H, Rendl M, Fuchs E. Tcf3 governs stem cell features and represses cell fate determination in skin. Cell. 2006. 127(1):171-83.
  • Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A. Noncatalytic requirement for cyclin A-cdk2 in p27 turnover. Mol Cell Biol. 2004. 24(13):6058-66.
  • Nguyen H, Gitig DM, Koff A. Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol Cell Biol. 1999. 19(2):1190-201.
  • Millard SS, Yan JS, Nguyen H, Pagano M, Kiyokawa H, Koff A. Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem. 1997. 272(11):7093-8.
  • Gudas J, Nguyen H, Li T, Hill D, Cowan KH. Effects of cell cycle, wild-type p53 and DNA damage on p21CIP1/Waf1 expression in human breast epithelial cells. Oncogene. 1995. 11(2):253-61.

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