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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Dario Marchetti, Ph.D.

Dario Marchetti, Ph.D.Professor
Department of Pathology and Immunology
Department of Molecular and Cellular Biology
Director of Circulating Tumor Cells Core

Phone: 713-798-2335
Fax: 713-798-1956


  • Ph.D., Molecular Biology, The University of Pavia, Pavia, Italy
  • Postdoctoral Fellow, Molecular Biology, University of Illinois, Chicago, IL
  • Postdoctoral Fellow, Neurochemisty, The University of Texas Medical Branch, Galveston, TX

Research Interests

  • Cancer invasion and metastasis
  • Brain metastasis
  • Angiogenic mechanisms in cancer and other pathologies

Selected Publications

  • Zhang L, Sullivan P, Suyama J, Marchetti D. Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer. Mol Cancer Res. 2010. 8(2):278-90.
  • Roy M, Marchetti D. Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis. J Cell Biochem. 2009. 106(2):200-9.
  • Brown AJ, Alicknavitch M, D'Souza SS, Daikoku T, Kirn-Safran CB, Marchetti D, Carson DD, Farach-Carson MC. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008. 43(4):689-99.
  • D'Souza S, Yang W, Marchetti D, Muir C, Farach-Carson MC, Carson DD.HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses. J Cell Biochem. 2008. 105(5):1183-93.
  • Marchetti D, Mrak RE, Paulsen DD, Sinnappah-Kang ND. Neurotrophin receptors and heparanase: a functional axis in human medulloblastoma invasion. J Exp Clin Cancer Res. 2007. 26(1):5-23.
  • Reiland J, Kempf D, Roy M, Denkins Y, Marchetti D. FGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cells. Neoplasia. 2006. 8(7):596-606.
  • Sinnappah-Kang ND, Mrak RE, Paulsen DB, Marchetti D. Heparanase expression and TrkC/p75NTR ratios in human medulloblastoma. Clin Exp Metastasis. 2006. 23(1):55-63.

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