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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Weei-Chin Lin, M.D., Ph.D.

Weei-Chin Lin, M.D., Ph.D.Associate Professor
Department of Medicine - Hematology and Oncology
Department of Molecular and Cellular Biology

Phone: 713-798-2641
Fax: 713-798-4055


  • M.D., National Taiwan University School of Medicine, Taipei, Taiwan
  • Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD
  • Postdoctoral, Johns Hopkins University School of Medicine, Baltimore, MD
  • Residency and Fellowship, Duke University Medical Center, Durham, NC

Research Interests

  • Cancer cell cycle
  • Gene expression and regulation
  • DNA damage response

Clinical Focus

  • Benign and malignant hematological disorders

Selected Publications

  • Paik JC, Wang B, Liu K, Lue JK, Lin WC. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem. 2010. 285(9):6348-63.
  • Wang B, Liu K, Lin HY, Bellam N, Ling S, Lin WC. 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010. 30(6):1508-27.
  • Liu K, Bellam N, Lin HY, Wang B, Stockard CR, Grizzle WE, Lin WC. Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol. 2009. 29(10):2673-93.
  • Yang SZ, Lin FT, Lin WC. MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep. 2008. 9(9):907-15.
  • Liu K, Paik JC, Wang B, Lin FT, Lin WC. Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J. 2006. 25(20):4795-807.
  • Luo Y, Lin FT, Lin WC. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol. 2004 Jul;24(14):6430-44.
  • Liu K, Luo Y, Lin FT, Lin WC. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev. 2004 Mar 15;18(6):673-86.

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