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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Joanna L. Jankowsky, Ph.D.

Joanna L. Jankowsky, Ph.D.Assistant Professor
Department of Neuroscience

Adjunct Assistant Professor
Departments of Neurosurgery and Neurology

Phone: 713-798-8377
Fax: 713-798-3946
Lab Web Site: Jankowsky Lab


  • Ph.D., Cellular and Molecular Neuroscience, California Institute of Technology, Pasadena, CA
  • Postdoctoral Fellow, Research Associate, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD
  • Senior Research Fellow, Division of Biology, California Institute of Technology, Pasadena, CA

Research Interests

  • Understanding the link between APP/Aβ and cognitive decline in Alzheimer's disease (AD)
  • Developing new therapeutic approaches to AD using mouse models
  • Selective neuronal silencing to study neuronal circuits in AD

Selected Publications

  • Badea A, Johnson GA, Jankowsky JL. Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. Neuroimage. 2010. 50(2):416-27.
  • Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem. 2007. 282(31):22707-20.
  • Verret L*, Jankowsky JL*, Xu GM, Borchelt DR, Rampon C. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. J Neurosci. 2007. 27(25):6771-80. *These authors contributed equally to this work.
  • Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci. 2005. 25(21):5217-24.
  • Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005. 2(12):e355.
  • Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004. 13(2):159-70.
  • Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging. 2004. 25(7):885-92.

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