Benjamin Deneen, Ph.D.
Department of Neuroscience
Center for Cell and Gene Therapy
- Ph.D., Molecular Biology, University of California, Los Angeles
- Postdoctoral Fellow, California Institute of Technology
- Delineating the molecular mechanisms that control neural stem cell differentiation into glial cells during embryogenesis
- Translating the basic mechanisms that control gliogenesis to glioma biology and treatment
- Relating the basic mechanisms that govern gliogenesis to neuro-degenerative disease
- Glioma biology – both basic and translational
- Neurodegenerative diseases – multiple sclerosis and spinal cord injury
- Song H-R, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Ji L, Gilles FH, Deneen B*, Erdreich-Epstein A*. Nuclear Factor I A is expressed in astrocytomas and is associated with improved progression-free survival. Neuro-Oncology. 2009 (in press). *Equal contribution.
- Hochstim CJ, Deneen B, Zhou Q, Anderson DJ. The spinal cord contains positionally distinct astrocyte subtypes whose identities are specified by a homeodomain transcriptional code. Cell. 2008. 133:510-22.
- Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006. 52:953-68.
- Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003. 23:3897-908.
- Deneen B, Denny CT. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001. 20:6731-41.