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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Benjamin Deneen, Ph.D.

Benjamin Deneen, Ph.D.Assistant Professor
Department of Neuroscience
Center for Cell and Gene Therapy

Phone: 713-798-7897
Fax: 713-798-1230
E-mail: deneen@bcm.edu

Education

  • Ph.D., Molecular Biology, University of California, Los Angeles
  • Postdoctoral Fellow, California Institute of Technology

Research Interests

  • Delineating the molecular mechanisms that control neural stem cell differentiation into glial cells during embryogenesis
  • Translating the basic mechanisms that control gliogenesis to glioma biology and treatment
  • Relating the basic mechanisms that govern gliogenesis to neuro-degenerative disease

Clinical Focus

  • Glioma biology – both basic and translational
  • Neurodegenerative diseases – multiple sclerosis and spinal cord injury

Selected Publications

  • Song H-R, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Ji L, Gilles FH, Deneen B*, Erdreich-Epstein A*. Nuclear Factor I A is expressed in astrocytomas and is associated with improved progression-free survival. Neuro-Oncology. 2009 (in press). *Equal contribution.
  • Hochstim CJ, Deneen B, Zhou Q, Anderson DJ. The spinal cord contains positionally distinct astrocyte subtypes whose identities are specified by a homeodomain transcriptional code. Cell. 2008. 133:510-22.
  • Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006. 52:953-68.
  • Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003. 23:3897-908.
  • Deneen B, Denny CT. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001. 20:6731-41.

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