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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Keith Syson Chan, Ph.D.

Keith Syson Chan, Ph.D.

Assistant Professor
Department of Urology
Department of Molecular and Cellular Biology

Phone: 713-798-5485
E-mail: kc1@bcm.edu

Education

  • Ph.D., The University of Texas, Graduate School of Biomedical Sciences, MD Anderson Cancer Center, Houston, TX
  • Postdoctoral Fellow, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA

Research Interests

  • Cancer stem cells
  • Tumor progression, metastasis
  • Self-renewal pathways, Stat3 signaling

Selected Publications

  • Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J Jr, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci USA. 2009. 106(33):14016-21.
  • Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, Digiovanni J. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene. 2008. 27(8):1087-94.
  • Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nature Medicine. 2005. 11(1):43-9. (*equal contribution)
  • Chan KS, Carbajal S, Kiguchi K, Clifford J, Sano S, DiGiovanni J. Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis. Cancer Research. 2004. 64(7):2382-9.
  • Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. Journal of Clinical Investigation. 2004. 114(5):720-8.

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