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Translational Biology & Molecular Medicine

Houston, Texas

Benchtop, Research, Bedside and Application
Translational Biology & Molecular Medicine Graduate Program
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Jason T. Yustein, M.D., Ph.D.

Jason T. Yustein, M.D., Ph.D.

Assistant Professor
Department of Pediatrics - Hematology and Oncology

Phone: 713-798-4450
E-mail: yustein@bcm.edu

Education

  • M.D., Ph.D., Case Western Reserve University
  • Residency, Johns Hopkins University
  • Fellowship, Johns Hopkins University and the National Cancer Institute

Research Interests

  • Osteosarcomas
  • Ewing's sarcoma
  • Cancer stem cells
  • Hypoxia-regulated genetic effects in tumors

Clinical Focus

  • Pediatric solid tumors
  • Osteosarcoma
  • Ewing's sarcoma
  • Rhabdomyosarcoma
  • Medical oncology

Selected Publications

  • Awad O*, Yustein JT*, Barber-Rotenberg J, Toretsky J, Loeb D. High aldehyde dehydrogenase activity identifies a chemotherapy-resistant population of Ewing's sarcoma cells with a stem cell phenotype that retains sensitivity to EWS-FLI1 inhibition. PLoS ONE. Under review. *Contributed equally to this manuscript.
  • Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A. 2010. 107(8):3534-9.
  • Dang CV, Kim JW, Gao P, Yustein JT. Interplay between Myc and HIF in cancer. Nat Rev Cancer. 2008. 8(1):51-6.
  • Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, Fu Y, Weng Z, Kuznetsov VA, Sung WK, Ruan Y, Dang CV, Wei CL. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A. 2006. 103(47):17834-9.
  • Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol. 2005. 25(14):6225-34.
  • Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. Oncogene. 2003. 22(40):6129-41.
  • Yustein JT, Li D, Robinson D, Kung HJ. KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. Oncogene. 2000. 19(5):710-8.

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