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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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David J. Tweardy, M.D.

David J. Tweardy, M.D.

Professor of Medicine
Chief, Section of Infectious Diseases


A.B., Princeton University, 1974
M.D., Harvard Medical School, 1978

Postgraduate Training

Resident in Medicine, Case Western Reserve University Hospitals of Cleveland 1979-1980
Fellow in Infectious Diseases, Case Western Reserve University Hospitals of Cleveland 1980-1982
Chief Resident in Medicine, Case Western Reserve University Hospitals of Cleveland 1982-1983
Research Associate in Infectious Diseases, Case Western Reserve University, Cleveland 1983-1984
Associate Scientist, The Wistar Institute, Philadelphia (Molecular Hematology, Giovanni Rovera, M.D., Laboratory Director), 1984-1986

Board Certification

Internal Medicine, Infectious Diseases


Infectious Diseases

Research & Clinical Interests

Dr. Tweardy's clinical research interests include the impact of trauma and shock on host susceptibility to hospital-acquired infections. His basic research interests include signal transduction events activated in cells and tissues by cytokines, focusing on signal tranducer and activator of transcription (STAT) 3.


  • Thacker SA, Robinson P, Abel A and Tweardy DJ. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep, 3:1187 (2013). PubMed
  • Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S; Children's Oncology Group. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood, 121(7):1083-93 (2013). PubMed
  • Anne Morrison C, Moran A, Patel S, Vidaurre Mdel P, Carrick MM and Tweardy DJ. Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock. J Infect, 66(1):87-94 (2013). PubMed
  • Liao KS, Lehman SM, Tweardy DJ, Donlan RM and Trautner BW. Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters. J Appl Microbiol, 113(6):1530-9 (2012). PubMed
  • Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B and Tweardy DJ. Substance P causes seizures in neurocysticercosis. PLoS Pathog, 8(2):e1002489, (2012). PubMed
  • Trautner BW, Lopez AI, Kumar A, Siddiq DM, Liao KS, Li Y, Tweardy DJ and Cai C. Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens. Nanomedicine, 8(3):261-70, (2012). PubMed
  • Roig IL, Musher DM and Tweardy DJ. Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis, 54(1):91-4, (2011). PubMed

For more publications, see listing on PubMed

Contact Information

One Baylor Plaza
BCM 286, Room N1319
Houston, TX 77030
Phone: 713-798-8918
Fax: 713-798-8948

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