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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Ido Golding, Ph.D.

Ido Golding, Ph.D.Assistant Professor

Department of Biochemistry & Molecular Biology

Baylor College of Medicine

Education

  • B.Sc., Physics, Technion, Israel Institute of Technology, 1991
  • M.Sc., Physics, Tel Aviv University, Israel, 1997
  • Ph.D., Physics, Tel Aviv University, Israel, 2001
  • Postdoctoral, Molecular Biology, Princeton University, 2006

Research Interests:

Using Physical Principles to Understand Living Systems

In our lab, we examine the way living cells process information from their environment and make decisions based on that information. Our aim is to form a quantitative narrative for the dynamics of cellular decision-making and unveil simple principles that underlie such processes. Our first model system is the bacterium E. coli and its virus, phage lamda. We examine their complex interaction at the level of individual events in space and time. More recently, we have begun to extend our studies to higher organisms.

Work in the lab involves a set of skills broader than what is generally mastered within a single discipline, including the techniques of molecular- and cell biology; live single-cell microscopy for making quantitative measurements; and data analysis using the engineer's toolbox of signal- and image processing; all accompanied by the theoretical tools of dynamical systems theory, stochastic processes, non-equilibrium phenomena and more. The practice of modern in vivo biology, combined with the intellectual effort of a quantitative approach, will contribute significantly to a young scientist's training experience, better preparing them for the future world of "Systems Biology".

mRNA diagram

Selected Publications:

  • Skinner SO, Sepúlveda LA, Xu H and Golding I. Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluroescent in situ hybridization. Nat Protoc, 8(6):1100-13 (2013). PubMed
  • Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ and Westbrook TF. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science, 335(6066):348-53 (2012). PubMed
  • Golding I. Decision making in living cells: lessons from a simple system. Annu Rev Biophys, 40:63-80 (2011). PubMed
  • So LH, Ghosh A, Zong C, Sepúlveda LA, Segev R and Golding I. General properties of transcriptional time series in Escherichia coli. Nat Genet, 43(6):554-60 (2011). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Biochemistry & Molecular Biology
Address: Baylor College of Medicine
One Baylor Plaza
Room 344EB
BCM125
Houston,Texas 77030
Phone: 713-798-4193
Fax: 713-796-9438
E-mail: golding@bcm.edu
Additional Links: Golding Lab

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