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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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David Gorenstein, Ph.D.

David Gorenstein, Ph.D.Professor & Deputy Director, The Brown Foundation Institute of Molecular Medicine

University of Texas Health Science Center at Houston


B.S., Massachusetts Institute of Technology
M.S. & Ph.D., Harvard University

Research Interests:

Proteomics and nanomedicine for both diagnostics and therapeutics in both infectious diseases and cancer; structural biology, drug design, nucleic acid and protein chemistry.

Selected Publications:

  • Thiviyanathan V and Gorenstein DG. Aptamers and the next generation of diagnostic reagents. Proteomics, 6(11-12):563-73 (2012). PubMed
  • He W, Elizondo-Riojoas MA, Li X, Lokesh GL, Somasunderam A, Thiviyanathan V, Volk DE, Durland RH, Englehardt J, Cavasotto CN and Gorenstein DG. X-aptamers: a bead-based selection method for random incorporation of druglike moieties onto next-generation aptamers for enhanced binding. Biochemistry, 51(42):8321-3 (2012). PubMed
  • Volk DE, Tuthill CW, Elizondo-Riojas MA and Gorenstein DG. NMR structural studies of thymosin α1 and ß-thymosins. Ann NY Acad Sci, 1270:73-8 (2012). PubMed
  • Prakash P, Sayyed-Ahmad A, Zhou Y, Volk DE, Gorenstein DG, Dial E, Lichtenberger LM and Gorfe AA. Aggregation behavior of ibuprofen, cholic acid and dodecylphosphocoline micelles. Biochim Biophys Acta, 18(12):3040-7 (2012). PubMed
  • Lichtenberger LM, Zhou Y, Jayaraman V, Doyen JR, O'Neil RG, Dial EJ, Volk DE, Gorenstein DG, Boggara MB and Krishnamoorti R. Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine. Biochim Biophys Acta, 1821(7):994-1002 (2012). PubMed
  • Elizondo-Riojas MA, Chamow SM, Tuthill CW, Gorenstein DG and Volk DE. NMR structure of human thymosin alpha-1. Biochem Biophys Res Commun, 416(3-4):356-61 (2011). PubMed
  • Mann AP, Bhavane RC, Somasunderam A, Liz Montalvo-Ortiz B, Ghaghada KB, Volk D, Nieves-Alicea R, Suh KS, Ferrari M, Annapragada A, Gorenstein DG and Tanaka T. Thioaptamer conjugated liposomes for tumor vasculature targeting. Oncotarget, 2(4):298-304 (2011). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: The Brown Foundation Institute of Molecular Medicine
Address: 1825 Pressler, Ste. 205
Phone: 713-500-2233
Additional Links: The Brown Foundation Institute of Molecular Medicine

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