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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Ted Wensel, Ph.D.

Ted Wensel, Ph.D.Chair, Verna and Marrs McLean Department of Biochemistry and Molecular Biology

Professor, Neuroscience, and Ophthalmology

SCBMB Executive Committee Member

Baylor College of Medicine

Education:

B.S., Chemistry, U. S. Fla. (1980)
Ph.D., Chemistry, U.C. Davis (1984)
Stanford, Cell Biology (1984-1988)

Research Interests:

Structural Dynamics of Signal Transducing Membranes
Dr. Wensel lab is using a multidisciplinary approach to understand the molecular mechanisms of G protein-mediated signal transduction in neurons of the retina and brain. New molecules and their functional roles are discovered, mechanisms of known molecules are explored at all levels from the atomic to the cellular, to intact animals. Techniques used include fluorescence spectroscopy and photobleaching recovery, electron and fluorescence microscopy, x-ray crystallography, genetics and reverse genetics, bioinformatics, biochemistry and molecular biology, and computational modeling of signaling pathways.

Selected Publications:

  • Price BA, Sandoval IM, Chan F, Nichols R, Roman-Sanchez R, Wensel TG and Wilson JH. Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant. PLoS One, 7(11):e49889 (2012). PubMed
  • Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W and Wensel TG. Three-dimensinal architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell, 151(5):1029-41 (2012). PubMed
  • Price BA, Sandoval IM, Chan F, Simons DL, Wu SM, Wensel TG and Wilson JH. Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci, 52(13)9728-36 (2011). PubMed
  • Gilliam JC and Wensel TG. TRP channel gene expression in the mouse retina. Vision Res, 51(23-24):2440-52 (2011). PubMed
  • Chan F, Hauswirth WW, Wensel TG and Wilson JH. Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice. Nucleic Acids Res, 39(14):5955-66 (2011). PubMed
  • Mojumder DK, Concepcion FA, Patel SK, Barkmeier AJ, Carvounis PE, Wilson JH, Holz ER and Wensel TG. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci, 51(11):5796-803 (2010). PubMed
  • Rodriguez GJ, Yao R, Lichtarge O and Wensel TG. Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors. Proc Natl Acad Sci USA, 107(17):7787-92 (2010). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Biochemistry and Molecular Biology
Address: Baylor College of Medicine
One Baylor Plaza
Room N430
BCM125
Houston, TX 77030
Phone: 713-798-6994
Fax: 713-796-9438
E-mail: twensel@bcm.edu
Additional Links: Wensel Lab, National Center for Macromolecular Imaging

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