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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Michael F. Schmid, Ph.D.

Michael F. Schmid, Ph.D.Associate Professor, Biochemistry & Molecular Biology

Co-Director, National Center for Macromolecular Imaging

Baylor College of Medicine


B.S. Chemistry, St. Joseph's College (1969)
Ph.D. Biochemistry, University of Washington, Seattle (1974)

Research Interests:

Computational methods in electron crystallography and image processing; 3-D reconstruction techniques; structure of macromolecular complexes (cytoskeleton, membrane proteins).

Selected Publications:

  • Schmid MF, Hecksel CW, Rochat RH, Bhella D, Chiu W and Rixon FJ. A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions. PLoS Pathog, 8(10):e1002961 (2012). PubMed
  • Prasad BV and Schmid MF. Principles of virus structural organization. Adv Exp Med Biol, 726:17-47 (2012). PubMed
  • Cong Y, Schröder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J and Chiu W. Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO J, 31(3):720-30 (2011). PubMed
  • Schmid MF. Single-particle electron crytomography (cryoET). Adv Protein Chem Struct Biol, 82:37-65, (2011). PubMed
  • Chen DH, Baker ML, Hryc CF, DiMaio F, Jakana J, Wu W, Dougherty M, Haase-Pettingell C, Schmid MF, Jiang W, Baker D, King JA and Chiu W. Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus. Proc Natl Acad Sci USA 108(4):1355-60, (2011). PubMed
  • Chang JT, Schmid MF, Haase-Pettingell C, Weigele PR, King JA and Chiu W. Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection. J Mol Biol, 402(4):731-40 (2010). PubMed
  • Murata K, Liu X, Danev R, Jakana J, Schmid MF, King J, Nagayama K and Chiu W. Zernike phase contrast cryo-electron microscopy and tomography for structure determination at nanometer and subnanometer resolutions. Structure, 18(8):903-12 (2010). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Biochemistry
Address: Baylor College of Medicine
One Baylor Plaza
Room N420.03
Houston, TX 77030
Phone: 713-798-5734
Fax: 713-798-1625
Additional Links: Biochemistry, National Center for Macromolecular Imaging

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