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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Florante Quiocho, Ph.D.

Florante Quiocho, Ph.D.Charles C. Bell Professor, Structural Biology

Professor, Biochemistry and Molecular Biology, Molecular Physiology and Biophysics

Baylor College of Medicine

Education:

B.S., Chemistry, Central Philippine Univ.
Ph.D., Molecular Biophysics and Biochemistry, Yale (1966)
Postdoctoral Fellow, Department of Chemistry, Harvard University

Research Interests:

Three-dimensional structures of biological macromolecules lie at the very core of understanding, at the atomic level, biological and biochemical processes. Our research interest is centered on the study of the three-dimensional structure and function of proteins and enzymes at atomic resolution. Although x-ray crystallography is the primary experimental approach to achieve this goal, other correlative studies employing biochemical, physical-chemical, and recombinant DNA techniques are also being pursued. The proteins under investigation cover the areas of signal transduction and cellular regulation, active transport, ligand and drug molecular recognition and vesicular trafficking and membrane fusion.

Selected Publications:

  • Alpadi K, Kulkarni A, Namjoshi S, Srinivasan S, Sippel KH, Ayscough K, Zieger M, Schmidt A, Mayer A, Evangelista M, Quiocho FA and Peters C. Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion. Nat Commun, 4:1704 (2013). PubMed
  • Huang Z, Srinivasan S, Zhang J, Chen K, Li Y, Li W, Quiocho FA and Pan X. Discovering thiamine transporters as targets of choloroquine using a novel functional genomics strategy. PLoS Genet, 8(11):e1003083 (2013). PubMed
  • Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ and Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. Proc Natl Acad Sci USA, 108(38):15757-62 (2012). PubMed
  • Srinivasan S, Vyas NK, Baker ML and Quiocho FA. Crystal structure of the cytoplasmic N-terminal domain of subunit l, a homolog of subunit a, of V-ATPase. J Mol Biol, 412(1):14-21 (2011). PubMed
  • Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL and Quiocho FA. Crystal structure of dimeriec cardiact L-type calcium channel regulatory domains bridged by Ca2+ calmoudulin. Proc Natl Acad Sci USA, 106(13):5135-5140 (2009). PubMed
  • Huang K, Ferrin-O'Connell I, Zhang W, Leonard GA, O'Shea EK and Quiocho FA. Structure of the Pho850-Pho809 CDK-cyclin complex of the phosphate-responsive signal transduction pathway. Mol Cell, 28(4):614-623 (2007). PubMed
  • Oldham ML, Khare D, Quiocho FA, Davidson AL and Chen J. Crystal Structure of a catalytic intermediate of the maltose transporter. Nature, 450(7169):515-521 (2007). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Biochemistry & Molecular Biology
Address: Baylor College of Medicine
One Baylor Plaza
Room T334A
BCM125
Houston, TX 77030
Phone: 713-798-6565
E-mail: faq@bcm.edu
Additional Links: Biochemistry

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