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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Timothy Palzkill, Ph.D.

Timothy Palzkill, Ph.D.The Cullen Trust for Higher Education Academic Chair

Professor and Chair, Pharmacology

Professor, Biochemistry & Molecular Biology

Baylor College of Medicine

Education:

B.S., Biology, Creighton University (1983)
Ph.D., Genetics, University of Iowa (1988)
Stanford University

Research Interests:

Protein structure and function studies on bacterial enzymes responsible for antibiotic resistance. These enzymes include beta-lactamases which catalyze the hydrolysis of penicillins and cephalosporins as well as a transpeptidase enzyme (PBP2a) from the bacterial pathogen Staphylococcus aureus which provides resistance to virtually all beta-lactam antibiotics.

Functional genomics studies on Treponema pallidum, the causative agent of syphilis. High-throughput techniques have been used to clone >95% of the open reading frames of this organism into protein expression vectors as well as vectors for phage display and two-hybrid analysis. These gene sets are being used to identify important antigens during T. pallidum infections and to map protein-protein interactions on the surface of the organism.

Selected Publications:

  • Brown NH, Chow DC and Palzkill T. BLIP-II is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2). Antimicrob Agents Chemother, 57(7):3398-401 (2013). PubMed
  • Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y and Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol, 87(8):4281-92 (2013). PubMed
  • Palzkill T. Metallo-ß-lactamase structure and function. Ann NY Sci, 1277:91-104 (2013). PubMed
  • Cai G, Deng L, Fryszcyzn BG, Liu Z, Jiang H, Palzkill T and Song Y. Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Med Chem Lett, 3(6):496-500 (2012). PubMed
  • Deng Z, Huang W, Bakkalbasi E, Brown NG, Adamski CJ, Rice K, Muzny D, Gibbs RA and Palzkill T. Deep sequencing of systematic combinatorial libraries reveals ß-lactamase sequence constraints at high resolution. J Mol Biol, 424(3-4):150-67 (2012). PubMed
  • McWilliams BD, Palzkill T, Weinstock GM and Petrosino JF. Identification of novel and cross-species seroreactive proteins from Bacillus anthracis using a ligation-independent cloning-based, SOS-inducible expression system. Microb Pathog, 53(5-6)250:8 (2012). PubMed
  • Chen P, Horton LB, Mikulski RL, Deng L, Sundriyal S, Palzkill T and Song Y. 2-Substituted 4, 5-dihydrothiazole-4-carbixylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett, 22(19):6229-32 (2012). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Molecular Virology & Microbiology
Address: Baylor College of Medicine
One Baylor Plaza
Room N520.01
BCM330
Houston, Texas 77030
Phone: 713-798-5609
Fax: 713-798-7375
E-mail: timothyp@bcm.edu

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