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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Rudy Guerra, Ph.D.

Rudy Guerra, Ph.D.Professor, Statistics

Rice University


B.S., Applied Mathematics, UT San Antonio
M.A., Mathematics, UC Berkeley
Ph.D., Statistics, UC Berkeley

Research Interests:

Dr. Guerra is interested in biological problems with an emphasis in biomedical research. Longtime collaboration with investigators from University of Texas Southwestern Medical Center have centered on statistical genetics whereby statistical methods are developed to analyze genetic data, especially with a view toward genotype-phenotype relationships. Such efforts include study design for genetic epidemiologic studies, linkage and association, and statistical models to account for both genetic and environmental factors influencing heritable traits. Current interests include meta-analysis for genetic linkage studies, case-control studies using haplotype blocks, and identification of multiple genetic markers influencing a single trait. More recently, he has been learning about bioinformatics via microarray studies and biological pathways. Projects in these areas are motivated by various system biology efforts with University of Texas Medical Branch (UTMB,Galveston), Baylor College of Medicine, and MD Anderson Cancer Center.

Selected Publications:

  • Guo B, Villagran A, Vannucci M, Wang J, Davis C, Man TK, Lau C and Guerra R. Bayesian estimation of genomic copy number with single nucleotide polymorphism genotyping arrays. BMC Res Notes, 3:350 (2010). PubMed
  • Cruz-Marcelo A, Guerra R, Vannucci,M, Li Y, Lau CC and Man TK Comparison of algorithms for pre-processing of SELDI-TOF mass spectrometry data. Bioinformatics, 24(19):2129-36 (2008). PubMed
  • Frye SR, Yee A, Eskin SG, Guerra R, Cong X and McIntire LV. cDNA microarray analysis of endothelial cells subjected to cyclic mechanical strain: importance of motion control. Physiol Genomics, 21(1):124-30 (2005). PubMed
  • Guerra R, Yu ZX, Marcovina S, Peshock R, Cohen JC and Hobbs HH. Lipoprotein(a) and apolipoprotein(a) isoforms- No association with coronary artery calcification in the Dallas Heart Study. Circulation, 111(12):1471-1479 (2005).
  • Jain T, Peshock R, McGuire DK, Willett D, Yu ZX, Vega GL, Guerra R, Hobbs HH and Grundy SM. African Americans and Caucasians have similar prevalence of coronary calcium in the Dallas heart study. Journal of the American College of Cardiology, 44(5):1011-1017 (2004).
  • Valentine RJ, Guerra R, Stephan P, Scoggins E, Clagett GP and Cohen J. Family history is a major determinant of subclinical peripheral arterial disease in young adults. Journal of Vascular surgery, 39(2):351-356 (2004).
  • Valentine J, Guerra R and Cohen J. Family History is a Major Determinant of Subclinical Peripheral Arterial Disease in Young Adults. Journal of Vascular Surgery (2003).

For more publications, see listing on PubMed.

Contact Information:

Department: Statistics
Address: 2100 Duncan Hall
Statistics Department
Rice University
Houston, TX 77005
Phone: 713-348-5453
Fax: 713-348-5476
Additional Links: Rice University

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