Wah Chiu, Ph.D.
Alvin Romansky Professor, Biochemistry & Molecular Biology
Professor, Molecular and Cellular Biology, Molecular Physiology & Biophysics, and Molecular Virology & Microbiology
Director, National Center for Macromolecular Imaging
Director of SCBMB Graduate Program
Baylor College of Medicine
B.A. Physics, University of California, Berkeley (1969)
Ph.D. Biophysics, University of California, Berkeley (1975)
Lawrence Berkeley National Laboratory (1979)
Our research is focused on the development of the high throughput methodology for electron cryomicroscopy and computational methods to solve 3-dimensional structures of macromolecular machines towards atomic resolution. The biological applications of our methodology include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Research effort is made to derive functions of the machine components via computational approaches.
Chen DH, Madan D, Weaver J, Schröder GF, Chiu W and Rye HS. Visualizing GroEL/ES in the Act of Encapsulating a Folding Protein. Cell, 153(6):1354-65 (2013). PubMed
Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ and Serysheva II. Validation of Cryo-EM Structure of IP3R1 Channel. Structure, 21(6):900-9 (2013). PubMed
Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupaimoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MM, King ER, Tekerdereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, and Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med, 366: 610-618 (2012). PubMed
Bammes BE, Rochat RH, Jakana J, Chen DH and Chiu W. Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency. J. Struct. Bio, 177: 589-601 (2012) PubMed
Cong Y, GF Schröder, AS Meyer, J Jakana, B Ma, MT Dougherty, MF Schmid, S Reissman, M Levitt, SL Ludtke, J Frydman and W Chiu. Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. The EMBO J, 31(3):720-730 (2011). PubMed
- Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC and Chiu W. 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelen equine encephalitis virus. The EMBO J. 30(18): 3854-3863 (2011). PubMed
- Lawson CL, ML Baker, C Best, C Bi, M Dougherty, P Feng, G van Ginkel, B Devkota, I Lagerstedt, SJ Ludtke, RH Newman, TJ Oldfield, I Rees, G Sahni, R Sala, S Velankar, J Warren, JD Westbrook, K Henrick, GJ Kleywegt, HM Berman, and W Chiu. EMDataBank.org: unified data resource for CryoEM. Nucleic Acids Res, 39:D456-64 (2011). PubMed
For more publications, see listing on PubMed.
Department: Biochemistry and Molecular Biology
Address: Baylor College of Medicine
One Baylor Plaza
Houston, Texas 77030
Additional Links: National Center for Macromolecular Imaging, Biochemistry and Molecular Biology