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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Yongtao Guan, Ph.D.

Yongtao Guan, Ph.D.

Assistant Professor, Departments of Pediatrics and Molecular and Human Genetics
Baylor College of Medicine


Ph.D., University of Idaho, 2006
Postdoc, University of Chicago, 2010

Research Interest:

Dr. Guan is a statistical geneticist with research interests in statistical methods of disease mapping. He developed and maintains the software package, BIMBAM (Bayesian IMputation Based Association Mapping). He has recently developed a method for multi-SNP association mapping via Bayesian Variable Selection (a software package that will soon be released to the public). He has also proposed to model epistatic interaction via directed acyclic graphs (DAG).

As a mathematician turned statistician, Dr. Guan maintains research interests in theory and algorithm development of Markov chain Monte Carlo, a stochastic scheme for computation and simulation. He developed a novel sampling scheme that is a combination of tempering, passing information via empirical distribution, and the small world sampling. He is working to extend the convergence theory of the new sampling algorithm to complex structures such as graphs and trees - the cornerstones of modern genetics.

Dr. Guan is also interested in the mathematical and statistical modeling of processes that arise from genetics and genomics, for example, genetic variation, recombination, and gene networks. He is constantly seeking collaborations with research groups that produce interesting data sets.

Selected Publications

  • Reddy KR, Guan Y, Qin G, Zhou Z and Jing N. Combined treatment targeting HIF1α and Stat3 is a potent strategy for prostate cancer therapy. Prostate, 71(16):1796-809 (2011). PubMed
  • Guan Y, Reddy KR, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL and Jing N. G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. Mol Ther, 18(1):188-97 (2010). PubMed
  • Zhou Z, Bernardo A, Zhu Q, Guan Y, Sun W, Lopez JA, Jing N and Dong JF. A G-quartet oligonucleotide blocks glycoprotein lb-mediated platelet adhesion and aggregation under flow conditions. Thromb Haemost, 102(3):529-37 (2009). PubMed
  • Mims MP, Guan Y, Pospisilova D, Priwitzerova M, Indrak K, Ponka P, Divoky V and Prchal JT. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood, 105(3):1337-42 (2005). PubMed

For more publications, see listing in PubMed.

Contact Information

Department: Departments of Pediatrics and Molecular and Human Genetics
Address: Baylor College of Medicine
USDA Children's Nutrition Research Center
1100 Bates St., Ste. 2070
Houston, TX, 77030,
Phone: 713-798-0362
Fax: 713-798-7098
Additional Links: Statistical Genetics Laboratory

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