Patrick Barth, Ph.D.
Department of Pharmacology
Department of Biochemistry & Molecular Biology
Baylor College of Medicine
Ph.D., University of Paris XI, France
Postdoctoral, University of California, Berkeley and University of Washington
Dr. Barth's lab is interested in how signals are faithfully transmitted across biological membranes. How do receptors sense and respond to diverse ligands? How do receptors communicate with each other in the membrane? How do receptor-receptor interactions modulate signaling? Can we recapitulate these properties by design and rewire signaling pathways?
The lab addresses these questions using a combination of molecular modeling, bioinformatics and experimental approaches to model, design and reprogram receptor/ligand interaction networks. Their long-term goal is to deconstruct the complex function and quantitatively describe the basic principles underlying these signaling networks.
They have developed an ensemble of physical models and computational methods to model and design receptor structures and interactions. They have also combined experimental data with modeling techniques to model specific functional states of receptors. Finally, they have cross-validated our predictions experimentally. This interdisciplinary approach is essential to our research and we welcome students and postdocs with computational and experimental backgrounds to continue fostering a very collaborative environment in the lab.
Selected Publications: (* these authors contributed equally)
- Chen KY, Zhou F, Fryszcyzn BG and Barth P. Naturally evolved G protein-coupled receptors adopt metastable conformations. Proc Natl Acad Sci USA, 109(33):13284-9 (2012). PubMed
- Barth, P, Zhu J, Luo BH, Schonbrun J, Baker D and Springer T. The structure of a receptor with two associating transmembrane domains on the cell surface : integrin aIIbb3. Molecular Cell 34(2), 234-49 (2009).
- Barth P, Wallner B and Baker D. Prediction of membrane protein structures with complex topologies using limited constraints. Proc Natl Acad Sci U S A (Track II) 106(5), 1409-14 (2009). PubMed
- Barth P, Schoeffler A and Alber T. Targeting metatstable coiled-coil domains by computational design. Journal of the American Chemical Society, 130(36), 12038-44 (2008). PubMed
- Barth P. Modulating membrane protein stability and association by design. Current Opinion in Structural Biology, 17(4), 460-466 (2007). PubMed
- Pathak M, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F and Isacoff EU. Closing in on the resting state of the shaker K+ channel. Neuron, 56(1), 124-140 (2007). PubMed
Barth P, Schonbrun J and Baker D. Toward high-resolution prediction and design of transmembrane helical protein structures. Proc Natl Acad Sci U S A (Track II), 104(40), 15682-15687 (2007). PubMed
For more publications, see listing on PubMed.
Address: BCM-Alkek Graduate School, BCMN-520.06