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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Course Descriptions

GS-SB-401 Computational Mathematics for for Quantitative Biomedicine

Provide an in-depth introduction to the critical mathematical concepts in structural biology, biochemistry, cell biology, neurobiology, genomics, physiology, and clinical medicine. Each lecture includes the underlying mathematics or computational principles important to either an experimental observation or computer simulation in the context of biology and medicine. After introducing mathematical concepts the lecturer will relate these concepts to one or more biological applications. Credits: 8 Term: 1-2 Director: Dr. Wah Chiu

GS-SB-403 Advanced Crystallography

X-ray crystallography is currently the most powerful technique to determine high resolution structures from small molecules and supramacromolecular assemblies alike. No course has yet been in place at BCM or any neighboring institution to teach this rapidly growing technique at the advanced level. The course will prepare SCBMB student who come from very diverse backgrounds to understand the power of protein crystallography as an analytical tool to probe the structure-function relationship of proteins and enzymes at the molecular level. Credits: 3 Term: 4 Director: Dr. Francis Tsai

GS-SB-404 KECK Seminar (Seminar in Computational Biology BIOS 592)

KECK Joint seminar in structural and computational biology. A joint seminar with the schools of the Gulf Coast Consortium with presentations of seminars by selected faculty and students on the general topic of structural and computational biology. Credits: 2 Term: 1, 3 Director: Dr. Wah Chiu

GS-SB-405 Computer-Aided Discovery Methods

The objective of this course is to introduce students to the concepts, methods and tools relevant for computer-aided discovery using data collected using high-throughput technologies. The course will focus on the methods of integration of data, tools, and discovery processes and the methods of computational pattern discovery, hypothesis generation and testing. The students will master advanced applications of computing that enable new methods of discovery in a field of focus, which will initially be cancer biology. The course will not focus exclusively on technical, algorithmic or mathematical aspects nor will it focus on biology alone. Instead, the focus will be on genuine integration of the two fields. Credits: 3 Term: 4 Director: Dr. Aleksander Milosavljevic

GS-SB-406 Practical Introduction to Programming for Scientists

This course will provide scientists with basic programming skills for simple tasks, and to make better use of the programmability available in many modern applications. For example, a scientific visualization package may have a programming interface that allows users to build animation scripts, image processing packages have interfaces that permit analytical measurements or complex batch processing on sets of images, etc. Students will learn Python and Ruby, the two most common scripting languages in scientific programming, and be introduced to other languages such as Perl, C++ and Java. These languages will run on virtually any computer, are freely available, and interface with many different scientific software packages. This course is aimed at students ranging from those with absolutely no programming background to those who have rudimentary programming skills. Some basic familiarity with using a computer will be expected. The course will be taught by Dr. Ludtke (Python/structural biology) and Andrew Jackson (Ruby/genetics). Access to a computer, and preferably a laptop is required for this class. Credits: 3 Term:3 Director: Dr. Steve Ludtke

GS-SB-410 Electron Microscopy for Molecules and Cells (odd years only)

This course discusses in-depth theoretical and practical techniques in structural biophysics with a particular emphasis on electron imaging and crystallography. Computer assignments will be required. Credits: 3 Term: 4 Director: Dr. Wah Chiu

GS-SB-423J Structural Basis of Human Diseases

This course is designed for medical and graduate students to understand the potential use of structural information for solving disease problems and to be aware of the different structural and computational tools. Each 1 hour lecture will be taught in the second term jointly by two or more instructors who will present the medical problems and the structural approaches towards solving them. Computer graphics will be used during the lecture period. Attendance is required for passing this course. Credits: 1 Term: 4 Director: Dr. B. Prasad

GS-SB-430 Advanced Topics in Structural & Computational Biology

This course is offered in Terms 1, 2, and 4. SCBMB faculty informs first-year students about their research activities in the first two terms. Advanced SCBMB graduate students present their research in the fourth term. The course is offered once a week for a one-hour credit for each term on Fridays from 12:00 noon to 1:00 p.m. This course allows a broader and more even exposure of our incoming students to the faculty and our senior graduate students. Furthermore, the course provides an opportunity to our senior graduate students to talk to the fellow students and faculty. No exams are administered for this course. Students will be given a grade of either pass or fail. The program administrator records attendance each week. Credits: TBA Term: 1, 2, 4 Director: Dr. Wah Chiu

GS-SB-435 Special Projects

Faculty mentored research for students that have not been admitted to candidacy. Credits: TBA Term: 1-5 Director: Faculty

GS-SB-463 Special Topics

Scholarly study directed by a faculty member. Special topics allows a faculty member to develop individualized courses for students. Special topics cannot be used to satisfy the 30 hr course requirement. Credits: TBA Term: 1-5 Director: Faculty

GS-SB-548 Readings

Faculty directed literature projects that survey a specialized topic of interest. Credits: Term: 1 Director: Dr. Wah Chiu

GS-SB-549 Research Rotation

Faculty mentored research for students who have not yet selected a faculty advisor. Credits: TBA Term: 1-5 Director: Faculty

GS-SB-550 Dissertation

Thesis research directed by a faculty mentor and advisory committee. Open only to candidates for the Ph.D. or M.S. degree. Credits: TBA Term: 1-5 Director: Faculty

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