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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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Wah Chiu, Ph.D.

Wah Chiu, Ph.D.Alvin Romansky Professor, Biochemistry & Molecular Biology

Professor, Molecular and Cellular Biology, Molecular Physiology & Biophysics, and Molecular Virology & Microbiology

Director, National Center for Macromolecular Imaging

Director of SCBMB Graduate Program

Baylor College of Medicine

Education:

B.A. Physics, University of California, Berkeley (1969)
Ph.D. Biophysics, University of California, Berkeley (1975)
Lawrence Berkeley National Laboratory (1979)

Research Interests:

Our research is focused on the development of the high throughput methodology for electron cryomicroscopy and computational methods to solve 3-dimensional structures of macromolecular machines towards atomic resolution. The biological applications of our methodology include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Research effort is made to derive functions of the machine components via computational approaches.

Selected Publications:

  • Chen DH, Madan D, Weaver J, Schröder GF, Chiu W and Rye HS. Visualizing GroEL/ES in the Act of Encapsulating a Folding Protein. Cell, 153(6):1354-65 (2013). PubMed
  • Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ and Serysheva II. Validation of Cryo-EM Structure of IP3R1 Channel. Structure, 21(6):900-9 (2013). PubMed
  • Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupaimoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MM, King ER, Tekerdereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, and Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med, 366: 610-618 (2012). PubMed
  • Bammes BE, Rochat RH, Jakana J, Chen DH and Chiu W. Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency. J. Struct. Bio, 177: 589-601 (2012) PubMed
  • Cong Y, GF Schröder, AS Meyer, J Jakana, B Ma, MT Dougherty, MF Schmid, S Reissman, M Levitt, SL Ludtke, J Frydman and W Chiu. Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. The EMBO J, 31(3):720-730 (2011). PubMed
  • Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC and Chiu W. 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelen equine encephalitis virus. The EMBO J. 30(18): 3854-3863 (2011). PubMed
  • Lawson CL, ML Baker, C Best, C Bi, M Dougherty, P Feng, G van Ginkel, B Devkota, I Lagerstedt, SJ Ludtke, RH Newman, TJ Oldfield, I Rees, G Sahni, R Sala, S Velankar, J Warren, JD Westbrook, K Henrick, GJ Kleywegt, HM Berman, and W Chiu. EMDataBank.org: unified data resource for CryoEM. Nucleic Acids Res, 39:D456-64 (2011). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Biochemistry and Molecular Biology
Address: Baylor College of Medicine
One Baylor Plaza
Room N420
BCM125
Houston, Texas 77030
Phone: 713-798-6985
Fax: 713-798-8682
E-mail: wah@bcm.edu
Additional Links: National Center for Macromolecular Imaging, Biochemistry and Molecular Biology

Updated 9/10

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