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Structural and Computational Biology and Molecular Biophysics

Houston, Texas

A BCM research lab.
Structural and Computational Biology & Molecular Biophysics
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William Brinkley, Ph.D.

William Brinkley, Ph.D.Distinguished Service Professor, Molecular and Cellular Biology

Baylor College of Medicine


Ph.D., Iowa State University
Postdoc, The University of Texas MD Anderson Cancer Center

Research Interests:

Structure and assembly of the mitotic apparatus; molecular mechanisms for aneuploidy and genomic instability in tumor cells.

Selected Publications:

  • Brinkley BR. Mitotic checkpoints, MUGs and kinetochores. Cell Cycle, 12(12) (2013). PubMed
  • Slattery SD, Newberg JY, Szafran AT, Hall RM, Brinkley BR and Mancini MA. A framework for image-based classification of mitotic cells in asynchronous populations. Assay Drug Dev Techol., 10(2):161-78 (2012). PubMed
  • Slattery SD, Mancini MA, Brinkley BR and Hall RM. Aurora-C kinase supports mitotic progression in the absence of Aurora-B. Cell Cycle, 8(18):2984-94 (2009). PubMed
  • Slattery SD, Moore RV, Brinkley BR and Hall RM. Aurora-C and Aurora-B share phophorylation and regulation of CENP-A and Borealin during mitosis. Cell Cycle, 7(6):787-95 (2008). PubMed
  • Caulin C, Ngyuen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G and Roop DR. An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J. Clin. Invest, 117(7):1893-901 (2007). PubMed
  • MacCorkle RA, Slattery SD, Nash DR and Brinkley BR. Intracellular protein binding to asbestos induces aneuploidy in human lung fibroblasts. Cell Motil Cytoskeleton, 63(10):646-57 (2006). PubMed
  • Nishino M, Kurasawa Y, Evans R, Lin SH, Brinkley BR and Yu-Lee LY. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Curr Biol., 16(14):1414-21 (2006). PubMed

For more publications, see listing on PubMed.

Contact Information:

Department: Molecular & Cellular Biology
Address: Room N204
Baylor College of Medicine
One Baylor Plaza
Houston, Texas 77030
Phone: 713-798-5263
Fax: 713-798-6325

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