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Houston, Texas

CMB research is conducted at Baylor College of Medicine in the Texas Medical Center, Houston.
Integrative Molecular and Biomedical Sciences Graduate Program
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Kendal Hirschi, Ph.D.

Kendal Hirschi, Ph.D.
Associate Professor
Departments of Pediatrics and Molecular and Human Genetics
Ph.D., University of Arizona
Post-doctoral, Whitehead Institute

Research Interests:

We study both model systems biology in plants as well as translational research related to agricultural improvement. At the molecular level, our goals are to understand the structure, biological function, and regulation of transporter proteins that control trafficking into and out of the plant vacuole. Many of our molecular approaches use the standard genetic “tool kit”.

Another major goal in our group is to learn how to manipulate the expression and function of these transporters to increase the nutritional content of crop plants, improve plant productivity, and cleanse polluted soils. For this second objective, we collaborate with faculty at the Children’s Nutrition Research here at Baylor and faculty at the Vegetable and Fruit Improvement Center at Texas A&M. Obtaining help from nutritional scientists, we perform clinical trials addressing how changes in plant architecture alter nutrient bioavailability.

Selected Publications:

Morris J, Nakata P, McConn M, Brock A, Hirschi KD (2007). Increased calcium bioavailability in mice fed genetically engineered plants lacking calcium oxalate (Cover).Plant. Mol. Biol. 64: 613-618.

Cheng NH, Liu JZ, Brock A, Nelson RA, Hirschi KD (2006). AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage. J. Biol. Chem. 281: 26280-26288.

Shigaki T, Hirschi, KD (2006). Diverse Functions and Molecular Properties Emerging for CAX Cation/H+ Exchangers in Plants. Plant Biol. 8: 419-429

Shigaki T, Rees I, Nakhleh L, Hirschi KD (2006). Identification of the three distinct phylogenetic groups of CAX cation/proton antiporters. J. Mol. Evol. 63: 815-825.

Park S, Li J, Pittman JK, Berkowitz GA, Yang H, Undurraga S, Morris J, Hirschi KD, Gaxiola RA (2005). Up-regulation of a H+-pyrophosphatase (H+-PPase) as a strategy to engineer drought-resistant crop plants.Proc. Natl. Acad. Sci. USA 102: 18830-18835.

Park S, Cheng NH, Pittman JK, Yoo KS, Park J, Smith RH, Hirschi KD (2005). Increased Calcium Levels and Prolonged Shelf Life in Tomatoes Expressing Arabidopsis H+/Ca2+ Transporters. Plant Phys. 139: 1194-12061.

Cheng NH, Pittman JK, Shigaki T, Lachmansingh J, Leclere S, Lahner B, Salt DE, Hirschi KD (2005). Functional Association of Arabidopsis CAX1 and CAX3 Is Required for Normal Growth and Ion Homeostasis. Plant. Physiol. 138: 2048-2060.

Shigaki T, Barkla BJ, Miranda-Vergara MC, Zhao J, Pantoja O, Hirschi KD (2005). Identification of a crucial histidine involved in metal transport activity in the Arabidopsis cation/H+exchanger CAX1. J. Biol. Chem. 280:30136-30142.

Park S, Kang TS, Kim CK, Han JS, Kim S, Smith RH, Pike LM, Hirschi KD (2005). Genetic Manipulation for Enhancing Calcium Content in Potato Tuber. J. Agric. Food Chem. 53: 5598-5603.

Cheng N, Liu J, Nelson S, Hirschi K. (2004) Characterization of CXIP4, a novel Arabidopsis protein that activates the H+/Ca2+ antiporter, CAX1. FEBS Letters 559:99-106 .

Cheng N, Pittman J K,Zhu K, and Hirschi K. (2004) The Protein Kinase SOS2 Activates the Arabidopsis H+/Ca2+ Antiporter CAX1 to Integrate Calcium Transport and Salt Tolerance. J. Biol. Chem. 279:2922-2926.

Hirschi K. (2004) The Calcium Conundrum. Both Versatile Nutrient and Specific Signal. Plant Phys. 136:2338-2342.

Sze H, et al. (2004) Expression Patterns of a Novel AtCHX Gene Family Highlight Potential Roles in Osmotic Adjustment and K1 Homeostasis in Pollen Development. Plant Phys. 136:2532-2547.

Cheng N, Hirschi K. (2003) Cloning and Characterization of CXIP1, a Novel PICOT Domain-containing Arabidopsis Protein That Associates with CAX1. J. Biol. Chem. 278:6503-6509.

Cheng N, Pittman JK, Barkla B, Shigaki T, Hirschi K. (2003) The Arabidopsis cax1 Mutant Exhibits Impaired Ion Homeostasis, Development, and Hormonal Responses and Reveals Interplay among Vacuolar Transporters. Plant Cell 15:347-364.

For more publications, see listing on PubMed.

Contact Information:

Kendal Hirschi, Ph.D.
Phone: (713) 798-7011
Fax: (713) 798-7078

Updated: 8/07

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