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Jeff Neul

Jeffrey L. Neul

E-mail: jneul@bcm.edu

Associate Professor, Baylor College of Medicine

B.S., University of Illinois at Urbana-Champaign, Urbana, 1991
M.D./Ph.D., University of Chicago, IL, 1998
Fellow, Baylor College of Medicine, Houston, TX, 2002-05


Rett Syndrome pathophysiology and treatment

  • Interested in translating knowledge acquired from basic science research into potential therapies for Rett syndrome

  • Actively using animal models of Rett syndrome to elucidate the pathophysiological mechanisms of disease and to conduct preclinical trials of potential therapies

Selected Publications

Neul JL, Zoghbi HY (2004) Rett syndrome: a prototypical neurodevelopmental disorder. Neuroscientist 10:118-128.

Neul JL, Maricich SM, Islam M, Barrish J, Smith EO, Bottiglieri T, Hyland K, Humphreys P, Percy A, Glaze D (2005) Spinal fluid 5-methyltetrahydrofolate levels are normal in Rett syndrome. Neurology 64:2151-2152.

del Gaudio D, Fang P, Scaglia F, Ward PA, Craigen WJ, Glaze DG, Neul JL, Patel A, et al. (2006) Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males. Genetics in Medicine 8:784-792.

Samaco RC, Fryer JD, Ren J, Fyffe S, Chao HT, Sun Y, Greer JJ, Zoghbi HY, Neul JL (2008) A partial loss of function allele of Methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Human Molecular Genetics 17:1718-1727.

Neul JL, Fang P, Barrish J, Lane J, Caeg EB, Smith EO, Zoghbi H, Percy A, Glaze DG (2008) Specific mutations in Methyl-CpG-Binding Protein 2 confer different severity in Rett syndrome. Neurology 70:1313-1321.

Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY (2008) Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron 59:947-958.

Glaze DG, Percy AK, Motil KJ, Lane JB, Isaacs JS, Schultz RJ, Barrish JO, Neul JL, O'Brien WE, Smith EO (2009) A study of the treatment of Rett syndrome with folate and betaine. Journal of Child Neurology 24:551-556.


Contact Information

Jeffrey L. Neul, M.D., Ph.D.
Department of Pediatrics - Neurology
Baylor College of Medicine
1250 Moursund St. - NRI, Suite N1250.18
Houston, Texas 77030, U.S.A.

Tel: (832) 824-8808
Fax: (832) 825-1249
E-mail: jneul@bcm.edu

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