Graduate School of Biomedical Sciences

Bacteria

Master
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Profiles of Faculty Working on Bacteria

People
First Name
David
Middle Name
B.
Last Name
Bates
Position
Associate Professor
First Name
Philip
Middle Name
J
Last Name
Hastings
Honorific Title
Ph.D.
Position
Professor
First Name
Christophe
Last Name
Herman
Honorific Title
Ph.D.
Position
Professor
First Name
James
Middle Name
R
Last Name
Lupski
Honorific Title
M.D., Ph.D., D.Sc. (hon)
Position
The Cullen Foundation Endowed Chair in Molecular Genetics
First Name
Susan
Middle Name
M
Last Name
Rosenberg
Honorific Title
Ph.D.
Position
Ben F. Love Chair in Cancer Research
First Name
Buck
Last Name
Samuel
Honorific Title
Ph.D.
Position
Assistant Professor
First Name
Jihye
Last Name
Yun
Honorific Title
Ph.D.
Position
Assistant Professor
Media Component
Media
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Research

Content

Stochastic switching of one cell in a clonal population in the same environment triggered by transcription errors. The growth of a single bacteria forming a microcolony was followed in a microfluidics flow chamber by time-lapse microscopy. The bright field frames are on the left, the GFP fluorescence frames are on the right and begin after the microcolony has become well established. The cell outlined in yellow is the cell that will change phenotype from lac OFF to ON, and the descendants of that cell will also manifest the ON phenotype. This video was created as part of the research for: Gordon AJ, Satory D, Halliday JA, Herman C. Heritable change caused by transient transcription errors. PLoS Genet. 2013 Jun;9(6):e1003595. doi: 10.1371/journal.pgen.1003595.

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