Department of Surgery

Funded Projects

Master
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RP-180674 (Vasudevan, Co-P.I.)

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Cancer Prevention and Research Institute of Texas
Predictive biomarkers and novel therapies for high-risk pediatric liver cancers.
Elucidate the mechanismas behind chemoresistance and vascular invasion in high-risk pediatric liver cancer. (1) Determine the major regulators of p53 tumor suppressor silencing and methods of reactivating tumor suppressor signaling in high-risk pediatric liver cancer. (2) Determine the differential gene expression and pathway regulation within areas of vascular invasion in high-risk HB in order to target susceptible pathways. (3) Test the susceptibility and response of patient-dervied xenografts from high-risk and relapse/refractory pediatric liver cancer patients to targeted MDM4/p53, JAK/STAT3 agents and GPC3 CAR T-cell immunotherapy.

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RP-170691 (Vasudevan, Subaward; Lewis, P.I.)

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Cancer Prevention and Research Institute of Texas
Patient-Derived Xenografts and Advanced In Vivo Models (PDX-AIM) Core Facility.
Develop patient-derived xenografts for pediatric and adult liver cancer using novel engrafting methods. (1) Improve tumor implantation rate for liver cancer PDX’s (2) Develop tumor spheroid and matrigel-coated plasticware techniques as intermediaries for biopsy samples (3) Use circulating tumor cells to generate PDX models when primary tissue samples are not available.

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(Vasudevan, P.I.)

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Macy Easom Cancer Research Foundation Grant
Development of novel targeted therapies for hepatoblastoma using patient-derived xenografts.
Establish a core panel of patient-derived xenografts and cell lines for high risk and relapsed hepatoblastoma patients. Test effects of MDM4 and DUSP9 inhibition on tumorigenesis of heptoblastoma.