Dr. Scott LeMaire (320x240)
Scott A. LeMaire, M.D.

Scott A. LeMaire, M.D., professor of surgery in the Division of Cardiothoracic Surgery and vice-chair for research in the Michael E. DeBakey Department of Surgery, was awarded an NIH R56 grant for his project, "Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and Dissections."

The overall objective of the project is to define the role of the NLRP3 inflammasome cascade, a multiprotein platform involved in amplifying intracellular stress responses, in promoting ascending aortic destruction and the extent to which this cascade represents a therapeutic target against ascending aortic aneurysms and dissections.

Through the proposed experiments, Dr. LeMaire, Hu Ying Shen, M.D., Ph.D., and their research team hope to identify a new, effective, pharmacological, prevention strategy that might delay or obviate invasive procedures in patients presenting with early-stage ascending aortic disease, suppress disease progression in patients who are poor candidates for surgical treatment, and improve the durability of surgical aortic repairs.