Bryan Burt, M.D. assistant professor of surgery and associate chief in the Division of General Thoracic Surgery, director of General Thoracic Surgery Research at Baylor College of Medicine, received the Dan L Duncan Comprehensive Cancer Center Pilot Project Program Award.
The project, "Window of opportunity clinical trial of neoadjuvant checkpoint inhibitor therapy for patients undergoing surgical resection of pleural mesothelioma," is an investigator-initiated, single institution, phase II clinical trial. Patients undergoing resection for pleural mesothelioma are administered anti-PDL1 and anti-CTLA-4 monoclonal antibodies to evaluate the influence of these drugs on intratumoral immune responses using time-of-light mass cytometry, RNA sequencing, and immunostaining. Dr. Burt is the primary investigator of the study.
Dr. Burt’s clinical practice includes the care of patients with thoracic malignancies and benign diseases of the esophagus, thoracic outlet, and chest wall. His clinical research interests include clinical effectiveness studies in minimally invasive approaches to thoracic malignancies. His interest in translational science is fulfilled by his clinical trials of immunotherapy for thoracic malignancies, and his studies of tumor immunology and novel therapeutic immunotherapies for lung cancer and mesothelioma.