Richard De La Garza, II, Ph.D.
Professor, Menninger Department of Psychiatry & Behavioral Science
Professor, Department of Pharmacology
Professor, Department of Neuroscience
Research Director and Associate Professor, University of Texas M.D. Anderson Cancer Center, Department of Psychiatry
Associate Professor, University of Texas M.D. Anderson Cancer Center, Department of Behavioral Sciences
Adjunct Associate Professor, University of Texas Medical Branch, Department of Pharmacology & Toxicology
Adjunct Associate Professor, University of Houston, Department of Psychology
Education and Awards
- B.S., 1985, Texas A&M University – East Texas
- M.S., 1989, University of North Texas
- Ph.D., 1996, University of Texas Medical Branch
- Post-Doctoral Fellow, 1999, Harvard Medical School
- Post-Doctoral Fellow, 2000, Yale University School of Medicine
- Kavli fellow, National Academy of Sciences
- American College of Neuropsychopharmacology-Upjohn Summer Research Fellowship
- Society for Neuroscience, Minority Neuroscientist Conference Fellowship
- American Society of Pharmacology and Experimental Therapeutics, Minority Young Scientist Travel Award
- Editorial Board, Journal of Addiction Research & Therapy; Journal of Drug Assessment
Dr. De La Garza serves as Principal- or Co-Investigator on several National Institute of Drug Abuse-funded trials to investigate the safety and efficacy of novel medications for methamphetamine and cocaine addiction. His emphasis is on acetylcholine (ACh) systems, including testing of acetylcholinesterase inhibitors, and other compounds that act directly or indirectly on ACh system functioning. Related to this, he is interested in the high rates of nicotine dependence in cocaine- and methamphetamine-dependent participants. He has forged collaborations with faculty who perform neuroimaging to elucidate the neural substrates associated with response to rewards, cues, and stressful stimuli in drug-dependent volunteers. His most recent research includes the use of virtual reality to evaluate physiological and subjective reactivity to 3D stimuli in the treatment of alcohol and nicotine addiction.
Mahoney, J.J., Jackson, B.J., Kalechstein, A.D., De La Garza, II, R., Newton, T.F. (2011) Acute, low-dose methamphetamine administration improves attention/information processing speed and working memory in methamphetamine-dependent individuals displaying poorer cognitive performance at baseline. Progr. Neuropsychopharm. Biol. Psych. 35: 459-65.
Culbertson, C., Nicolas, S., Zaharovits, I., London, E., De La Garza, II, R., Brody, A., Newton, T. (2010) Methamphetamine craving induced in an online virtual reality environment. Pharmacol. Biochem. Behav. 96: 454-60.
De La Garza, II, R., Zorick, T., London, E.D., Newton, T.F. (2010) Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers. Drug Alcohol Depend. 106: 173-80.
De La Garza, II, R., Zorick, T., Heinzerling, K.G., Nusinowitz, S., London, E.D., Shoptaw, S., Moody, D.E., Newton, T.F. (2009) The cardiovascular and subjective effects of methamphetamine combined with y-vinyl-y -aminobutyric acid (GVG) in non-treatment seeking methamphetamine-dependent volunteers. Pharmacol. Biochem. Behav. 84: 186-93.
De La Garza, II, R., Mahoney, III, J.J., Culbertson, C., Shoptaw, S., Newton, T.F. (2008) The acetylcholinesterase inhibitor rivastigmine does not alter total choices for methamphetamine, but may reduce positive subjective effects, in a laboratory model of intravenous self-administration in human volunteers. Pharmacol. Biochem. Behavior. 89: 200-208.
De La Garza, II, R., Shoptaw, S., Newton, T.F. (2008) Evaluation of the cardiovascular and subjective effects of rivastigmine in combination with methamphetamine in methamphetamine-dependent human volunteers. Intl. J. Neuropsychopharmacol. 11: 729-41.
Newton, T.F., Roache, J.D., De La Garza, II, R., Fong, T., Wallace, C.L., Li, S-H., Elkashef, A., Chiang, N., Kahn, R. (2006) Bupropion reduces methamphetamine-induced subjective effects and cue-induced craving. Neuropsychopharmacology 31: 1537-44.
De La Garza, II, R. (2005) Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia. Neurosci. Biobehav. Rev. 29: 761-770.
Jentsch, J.D., Olausson, J.P., De La Garza, II, R., Taylor, J.R. (2002) Impairments of reversal learning and response perseveration after subchronic cocaine administration in monkeys. Neuropsychopharmacology 26: 183-190.
Miller, G.M., De La Garza, II, R., Novak, M.K., Madras, B.K. (2001) Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles: Implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Mol. Psychiatry 6: 50-58.