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Pediatrics - Neurology/

Houston, Texas

Pediatrics - Neurology and Developmental Neuroscience
Pediatrics - Neurology/
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Hsiao-Tuan Chao, M.D., Ph.D.

Hsiao-Tuan Chao , M.D., Ph.D.Child Neurology Resident

Contact Information:
Hsiao-Tuan Chao, M.D., Ph.D.
6701 Fannin
Clinical Care Center, Suite 1250
Houston, TX 77030
Tel: 832-822-1750
Fax: 832-825-1717


M.D. - Baylor College of Medicine
Ph.D. - Neuroscience - Baylor College of Medicine
Pediatric Residency - Baylor College of Medicine

Research Interests

Elucidating the neuronal network, molecular signaling, and genetic basis of neuropsychiatric disorders.

Clinical Plans

Academic medicine, basic and translational neuroscience research.

Honors and Awards

2013 Journal of Child Neurology, Residents and Fellows section of the editorial board

2012 Drs. Benjamin and Margarie Mo Scholar, Chinese American Doctors Association of Houston

2012 Best Overall Performance in Medical School Award, Medical Scientist Training Program, Baylor College of Medicine

2011 Top 10 Autism Research Findings of 2010, Autism Speaks, Chao et al. Nature, 2010

Selected Publications

Chao HT and Zoghbi HY. MeCP2: only 100% will do. Nature Neuroscience. 2012 Jan 26;15(2):176-7. PMID: 22281712

Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT, Frankel WN. Etiology of a genetically complex seizure disorder in Celf4 mutant mice. Genes Brain Behav. 2011 Jul 11;10(7):765-77. PMID: 21745337

Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Heintz N, Ekker M, Rubenstein J, Noebels JL, Rosenmund C, Zoghbi HY. MeCP2 deficiency in GABAergic neurons mediates abnormal social behavior and key features of Rett syndrome. Nature. 2010 Nov 11;468(7321):263-9. PMID: 21068835

Xue M*, Craig TK*, Xu J, Chao HT, Rizo J, Rosenmund C. Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. *Equal contribution. Nat Struct Mol Biol. 2010 May;17(5):568-75. PMID: 20400951

Samaco RC, Mandel-Brehm C, Chao HT, Fyffe SL, Sun Y, Ren J, Hyland K, Maricich SM, Deneris ES, Greer JJ, Humphreys P, Percy A, Glaze DG, Thaller C, Zoghbi HY, Neul JL. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci. 2009 Dec 22;106(51):21966-71. PMID: 20007372

Rose MF*, Ren J*, Ahmad KA*, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. *Equal contribution. Neuron. 2009 Nov 12;64(3):341-54. PMID: 19914183

Chao HT, Zoghbi HY. The yin and yang of MeCP2 phosphorylation. Proc Natl Acad Sci. 2009 Mar 24; 106(12):4577-8. PMID: 19293386

Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goudling EH, Sullivan E, Tecott LH, Zoghbi HY. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, anxiety, and aggression. Neuron. 2008. Sep 25;59(6):947-58. PMID: 18817733

Samaco RC, Fryer JD, Ren J, Fyffe S, Chao HT, Sun Y, Greer JJ, Zoghbi HY, Neul JL. A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum Mol Genet. 2008 Jun 15;17(12):1718-27. PMID: 18321864

Chao HT, Zoghbi HY, Rosenmund C. MeCP2 controls synaptic strength in glutamatergic neurons by regulating synapse number. Neuron. 2007 Oct 4;56(1):58-65. PMID: 17920015

Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C. Distinct domains of Complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol. 2007 Oct;14(10):949-58. PMID: 17828276

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