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Pediatrics - Cardiology

Houston, Texas

BCM faculty, staff and trainees are the heart of the organization.
Pediatrics - Cardiology
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Clinical Research

As part of our ongoing commitment to provide the highest quality of patient care, the Section of Pediatric Cardiology at Baylor College of Medicine/the Heart Center at Texas Children's Hospital is a leader in clinical research. Our program actively participates in cutting-edge research that spans a broad range of clinical specialties. Inventions and discoveries by faculty of our group have been noteworthy since our early beginnings. They include the first transplant in a small child, the development of pediatric electrophysiology, inventions in cardiac catheterization and intervention, and the discovery of disease-causing genes and viral markers of acquired heart disease.

Heart Failure, Cardiomyopathy, and Transplant
Cardiac Catheterization
Echocardiography/Magnetic Resonance Imaging
Electrophysiology
Cardiovascular Intensive Care
Cardiovascular Genetics
Additional Projects

Heart Failure, Cardiomyopathy, and Transplant

  • Viral mechanisms of cardiac rejection in pediatric transplant patients
  • Arrhythmias and sudden cardiac death in children with dilated cardiomyopathy
  • Predictors of poor outcome in pediatric patients with dilated cardiomyopathy
  • Arginine vasopressin levels as a predictor of outcome in children with congestive heart failure
  • Use of nesiritide in the pediatric heart failure population
  • Evaluation of BNP levels in the pediatric population – utility in children with cardiomyopathy, status post cardiac transplantation, and congestive heart failure
  • Treatment and outcome of heart failure in patients with muscular dystrophy
  • Leukocyte suppression and outcomes in pediatric orthotopic cardiac transplantation
  • Telethonin – the link between structural abnormalities and arrhythmias
  • Incidence of thrombosis in restrictive cardiomyopathy
  • Abdominal pain in pediatric heart transplant recipients – a sign of graft vasculopathy

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Cardiac Catheterization

  • Patent ductus arteriosus characteristics – echocardiographic and angiographic predictors of suitability for interventional catheter closure
  • Non-invasive, real-time cardiac output evaluation
  • Long-term evaluation post stent placement in pulmonary arteries – impact on morbidity and mortality
  • Long-term follow-up after coil occlusion of coronary fistula
  • Balloon angioplasty of coarctation of aorta in 690-gram infant
  • Effect of coil occlusion of patent ductus arteriosus on atrial septal defect size
  • Long-term outcome of aorto-pulmonary collaterals in children with pulmonary atresia with ventricular septal defect
  • Interventional catheterization for pulmonary vein stenosis
  • Long-term outcome of balloon dilatation of aortic valve stenosis
  • Incidence of headaches post interventional atrial septal defect closure
  • Use and outcomes of expandable stents
  • Impact of stent placement in branch pulmonary arteries on degree of pulmonary regurgitation and right ventricular function

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Echocardiography/Magnetic Resonance Imaging

  • Utility of echocardiography in the evaluation of pediatric chest pain
  • Correlation of electrocardiogram abnormalities with echocardiographic findings in children
  • Echo evaluation of isolated aortic valve regurgitation – impact on surgical timing and long-term outcome
  • Peri-operative assessment of myocardial performance in neonates and children after cardiac repair
  • MRI changes in palliated patients with d-transposition of the great arteries
  • Echocardiographic predictors of outcome in restrictive cardiomyopathy
  • Growth of atrial septal defects during childhood
  • Harmonic imaging in pediatric echocardiography
  • 5th aortic arch – delineation by MRI
  • Utility of intracardiac echo probe for transesophageal cardiac evaluation in low-weight neonates during cardiac surgery
  • Utility of Doppler tissue imaging in predicting cardiac transplant rejection
  • Evaluation of ventricular function in pediatric cancer patients receiving anthracyclines
  • Evaluation and outcome of intracardiac thrombi
  • Echocardiographic predictors of surgical outcome in children with mitral stenosis
  • Rhabdomyomas and left ventricular outflow tract obstruction
  • Echocardiographic predictors of need for early intervention in patients with multiple left-sided obstructive lesions
  • Cardiac MRI evaluation of coronary arterial anatomy in children
  • Utility of Doppler tissue imaging in predicting outcome in children with dilated cardiomyopathy
  • Utility of Doppler tissue imaging in predicting outcome in children with hypertrophic cardiomyopathy
  • Utility of Doppler tissue imaging in predicting outcome in children with left ventricular non-compaction
  • Impact of cardiac growth on Doppler tissue imaging velocities in normal children
  • Determination of cardiac catheterization as a pre-requisite in all children undergoing bi-directional cavopulmonary anastomosis
  • Effect of altered loading conditions on Doppler indices of myocardial performance
  • Utility of hand-held echocardiography in the cardiovascular intensive care unit
  • Echo predictors of long-term outcome in tetralogy of Fallot with severe pulmonary regurgitation
  • Impact of anesthetic regimens on single ventricle function
  • Echocardiographic evaluation of fetal cardiac tumors

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Electrophysiology

  • Biventricular pacing in d-transposition of the great arteries in patients after Mustard palliation
  • Fetal arrhythmias – treatment strategies and outcome
  • Tachycardia-induced cardiomyopathy – mechanism of tachycardia and impact on left ventricular function
  • Pacemaker-associated cardiomyopathy
  • Electrocardiogram criteria for left ventricular hypertrophy in African-American children
  • Routine holters versus pacemaker checks for identification of abnormalities of pacemaker function
  • Wolff-Parkinson-White and dilated cardiomyopathy
  • Incidence of arrhythmias in patients post extracardiac versus lateral tunnel Fontan palliation
  • Use of pacemakers/defibrillators in post cardiac transplant patients
  • Electrocardiogram changes after atrial septal defect surgery
  • Combination of flecainide and sotalol to treat infant supraventricular tachycardia
  • Outcome in infants younger than one year of age requiring multiple drugs to control supraventricular tachycardia
  • Use of defibrillators in children with hypertrophic cardiomyopathy
  • Use of TPA post radiofrequency ablation
  • Ectopic atrial tachycardia – management and outcome

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Cardiovascular Intensive Care

  • Effects of perotineal dialysis on serum pro-inflammatory cytokine levels in neonates post cardiopulmonary bypass
  • BNP levels in neonates with single ventricles before and after Norwood and Glenn palliations
  • NIRS in single ventricle patients
  • Evaluation of BNP levels in the peri-operative pediatric population
  • Use of fenoldopam in peri-operative pediatric patients with hypertension
  • Peritoneal dialysis versus lasix infusion in neonates
  • Peri-operative cerebral and lower body oxygen saturation in neonates undergoing congenital heart surgery
  • Stress dose steroid rescue in critically ill neonates
  • Hyperventilation and cerebral vascular effects in children after bi-directional cavopulmonary anastomosis
  • Comparative study of peri-operative course and outcome in patients undergoing Fontan versus Fontan revision surgery
  • Acute effects of milrinone on diastolic properties after volume reduction surgery in single ventricle patients
  • Pediatric cardiac acuity score: Validation and use in pediatric cardiac intensive care unit
  • Use of endothelin antagonist in patients with congenital heart disease and pulmonary hypertension
  • Utility and complications of temporary pacing wires following cardiac surgery in children with congenital heart disease

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Cardiovascular Genetics

  • Effects of beta-blockade on aortic root growth in children with Marfan syndrome
  • Cardiac and overall outcome in children with trisomy 18

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Additional Projects

  • Use of caffeine citrate as prophylaxis for prostaglandin-induced apnea in neonates with ductal dependent congenital heart disease
  • Utility of ACE-inhibition in d-transposition of the great arteries in patients post Mustard palliation
  • Long-term outcomes in adults with congenital heart disease
  • Outcomes in adult patients with history of Kawasaki disease
  • Intimal constitution in aorto-pulmonary shunts
  • Incidence of sudden cardiac death in patients with Kawasaki disease
  • Worldwide experience with conjoined twins and septation
  • Double aortic arch in d-transposition of the great arteries
  • Regression of primary pulmonary hypertension
  • Neo-aortic root dilatation after arterial switch operation in d-transposition of the great arteries
  • Protein losing enteropathy – incidence and outcome
  • Institutional experience with coronary artery fistula
  • Heterotaxy syndrome – retrospective review of prognosis and outcome
  • Evaluation of malrotation in heterotaxy patients
  • Insurance and time to repair of congenital heart disease

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