Laising Yen, Ph.D.
- Ph.D. Yale University , New Haven , CT
- Yale University, School of Medicine
- Harvard Medical School
- RNA biology
- Molecular biology
Area of Interest
- The research goals of my laboratory are to harness the power of RNA to create new therapeutic instruments for medicine and biological studies. Our current research areas include: (1) The development of RNA-based molecular switches that can be turned on or off by small molecules for gene regulation, (2)the development of RNA-based cellular biosensors for detecting specific intracellular molecules in diseases, and (3) investigation of RNA mutations in human cancer for diagnosis and therapy.
See link (Laising Yen Lab) for details.
- Assistant Professor, Department of Pathology & Immunology
- Assistant Professor, Department of Molecular and Cellular Biology
- Duncan Scholar, Dan L. Duncan Cancer Center, Baylor College of Medicine
- Hereditary Disease Foundation, Post-doctoral Fellowship Grant
- Yale Graduate Fellowship
- Kalpana Kannan, Liguo Wang, Jianghua Wang, Michael Ittmann, Wei Li, and L. Yen. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep-sequencing. Proc Natl Acad Sci USA 108:9172-9177 (2011).
- Wang, L., Y. Xi, J. Yu, L. Dong, L. Yen, and W. Li. A Statistical Method for the Detection of Alternative Splicing Using RNA-seq. PLoS One 5:e8529 (2010).
- Yen, L., B.R. Stockwell, and R.C. Mulligan. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods in Molecular Biology, 540:335 (2009).
- Link K.H., L. Guo, T. Ames, L. Yen, R.C. Mulligan, and R.R. Breaker. Engineering high speed allosteric hammerhead ribozymes. Biological Chemistry, 388:779-786 (2007).
- Yen, L., M. Magnier, R. Weissleder, B.R. Stockwell, and R.C. Mulligan. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA, 12:797-806 (2006). PMID: 16556935.
- Yen, L., J. Svendsen, J-S. Lee, J.T. Gray, M. Magnier, T. Baba, R.J. D'Amato and R.C. Mulligan. Exogenous control of mammalian gene expression via modulation of RNA self-cleavage. Nature, 431:471-476 (2004). PMID: 15386015.
- Yen, L. Gonzalez-Zulueta M, Feldman A, Yuan Y, Fryer H, Dawson T, Dawson V, and R.G. Kalb. Reduction of functional NMDA Receptor in neurons by RNase P-mediated cleavage of the NR1 mRNA. J. Neurochem. 76:1386-94 (2001). PMID: 11238723.
- Yen, L., S.M. Strittmater and R.G. Kalb. Sequence-specific cleavage of Huntington mRNA by catalytic DNA. Annals of Neurology, 46:366-373 (1999). PMID: 10482267.
- Jakowec, M.W., L. Yen and R.G. Kalb. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience 67:909-920 (1995). PMID: 7675213.
- Yen, L. and R.G. Kalb. Recovery from spinal cord injury: New approaches. Neuroscientist, 1:321-327 (1995).
- Yen, L., J. Sibley and M. Constantine-Paton. Analysis of synaptic distribution within single retinal axonal arbors after NMDA treatment. J. Neurosci. 15:4712-4725 (1995). PMID: 7540683.
- Yen, L., J. Sibley and M. Constantine-Paton. Fine-structural alterations and clustering of developing synapses after chronic treatment with low levels of NMDA. J. Neurosci. 13:4949-4960 (1993). PMID: 8229207.
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