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Path-Immuno - Laising Yen Laboratory

Houston, Texas

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Path-Immuno - Laising Yen Laboratory
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Laising Yen, Ph.D.

Assistant Professor

Education

  • Ph.D. Yale University , New Haven , CT

Post-doctoral Training

  • Yale University, School of Medicine
  • Harvard Medical School

Specialty

  • RNA biology
  • Molecular biology

Area of Interest

  • The research goals of my laboratory are to harness the power of RNA to create new therapeutic instruments for medicine and biological studies. Our current research areas include: (1) The development of RNA-based molecular switches that can be turned on or off by small molecules for gene regulation, (2)the development of RNA-based cellular biosensors for detecting specific intracellular molecules in diseases, and (3) investigation of RNA mutations in human cancer for diagnosis and therapy.
    See link (Laising Yen Lab) for details.

Current Position

  • Assistant Professor, Department of Pathology & Immunology
  • Assistant Professor, Department of Molecular and Cellular Biology

Honors

  • Duncan Scholar, Dan L. Duncan Cancer Center, Baylor College of Medicine
  • Hereditary Disease Foundation, Post-doctoral Fellowship Grant
  • Yale Graduate Fellowship

Representative Publications

  • Kalpana Kannan, Liguo Wang, Jianghua Wang, Michael Ittmann, Wei Li, and L. Yen. Recurrent chimeric RNAs enriched in human prostate cancer identified by deep-sequencing. Proc Natl Acad Sci USA 108:9172-9177 (2011).
  • Wang, L., Y. Xi, J. Yu, L. Dong, L. Yen, and W. Li. A Statistical Method for the Detection of Alternative Splicing Using RNA-seq. PLoS One 5:e8529 (2010).
  • Yen, L., B.R. Stockwell, and R.C. Mulligan. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods in Molecular Biology, 540:335 (2009).
  • Link K.H., L. Guo, T. Ames, L. Yen, R.C. Mulligan, and R.R. Breaker. Engineering high speed allosteric hammerhead ribozymes. Biological Chemistry, 388:779-786 (2007).
  • Yen, L., M. Magnier, R. Weissleder, B.R. Stockwell, and R.C. Mulligan. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA, 12:797-806 (2006). PMID: 16556935.
  • Yen, L., J. Svendsen, J-S. Lee, J.T. Gray, M. Magnier, T. Baba, R.J. D'Amato and R.C. Mulligan. Exogenous control of mammalian gene expression via modulation of RNA self-cleavage. Nature, 431:471-476 (2004). PMID: 15386015.
  • Yen, L. Gonzalez-Zulueta M, Feldman A, Yuan Y, Fryer H, Dawson T, Dawson V, and R.G. Kalb. Reduction of functional NMDA Receptor in neurons by RNase P-mediated cleavage of the NR1 mRNA. J. Neurochem. 76:1386-94 (2001). PMID: 11238723.
  • Yen, L., S.M. Strittmater and R.G. Kalb. Sequence-specific cleavage of Huntington mRNA by catalytic DNA. Annals of Neurology, 46:366-373 (1999). PMID: 10482267.
  • Jakowec, M.W., L. Yen and R.G. Kalb. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience 67:909-920 (1995). PMID: 7675213.
  • Yen, L. and R.G. Kalb. Recovery from spinal cord injury: New approaches. Neuroscientist, 1:321-327 (1995).
  • Yen, L., J. Sibley and M. Constantine-Paton. Analysis of synaptic distribution within single retinal axonal arbors after NMDA treatment. J. Neurosci. 15:4712-4725 (1995). PMID: 7540683.
  • Yen, L., J. Sibley and M. Constantine-Paton. Fine-structural alterations and clustering of developing synapses after chronic treatment with low levels of NMDA. J. Neurosci. 13:4949-4960 (1993). PMID: 8229207.

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