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Path-Immuno - James Versalovic Lab

Houston, Texas

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Path-Immuno - James Versalovic Lab
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Tetrahydrofolate Synthesis (THFS) Gene Modulates the immune system

The anti-inflammatory effect of the probiotic Lactobacillus reuteri is dependent on the tetrahydrofolate sythensis gene.

--------In Vitro--------

The thfs1 gene contributes to the TNF suppressive ability of L. reuteri 6475 cell wall associated factors and cell-free supernatant.

--------In Vivo--------

TNBS Mouse Colitis Model

The thfs1 gene in L. reuteri 6475 is essential for the colitis attenuation activity of the supernatant.

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The thfs1 gene in L. reuteri 6475 is essential for the systemic anti-inflammatory activity of the supernatant.


Related Abstracts & Publications

  1. Thomas CM, Versalovic J. Probiotics-host communication: Modulation of signaling pathways in the intestine. Gut Microbes. 2010;1(3):1-16. Article
  2. Thomas CM, Preidis GA, Versalovic J. Mechanisms of immune enhancement by beneficial microbes and probiotics. Old Herborn University Seminar Monograph 24, article 8. 2011.
  3. Thomas CM, Saulnier D, Hong T, Kalkum M, Versalovic J. Identifying Potential Probiotic Immunomodulins and Understanding their Mechanisms of Action. National MD/PhD Student Symposium, Keystone, CO, 2010. Oral Presentation.
  4. Thomas CM, Saulnier D, Spinler JK, Lin YP, Hong T, Kalkum M, Versalovic J. Folate Derivatives Contribute to TNF Suppression by Lactobacillus reuteri through modulation of MAPK pathways. Baylor College of Medicine Interdepartmental Program of Cell and Molecular Biology Symposium, Houston, TX, 2010. Poster Presentation.
  5. Thomas CM, Saulnier D, Spinler JK, Lin YP, Hong T, Kalkum M, Versalovic J. Folate Derivatives Contribute to TNF Suppression by Lactobacillus reuteri through modulation of MAPK pathways. Baylor College of Medicine Medical Scientist Training Program Student Symposium, Houston, TX, 2010. Poster Presentation.

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