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Path-Immuno - James Versalovic Lab

Houston, Texas

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Path-Immuno - James Versalovic Lab
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Toni-Ann Mistretta, Ph.D.

Toni-Ann Mistretta, Ph.D.Senior Biostatistician,
Baylor College of Medicine &
Texas Children's Microbiome Center


832-824-2225 (tel)
832-825-1165 (fax)
toniannm@bcm.edu
Joined lab: 2008

Mailing Address:
Texas Children's Hospital
1102 Bates Avenue
Suite 830, Feigin Center
Houston, TX 77030

Current Role

Dr Mistretta supports the principal investigators and researchers in experimental design, consultation and statistical data analysis for a variety of clinical and research laboratory projects. She coordinates the communication and development of data analysis tools and pipeline for the Pediatric IBS Microbiome Project between researchers, the Bioinformatics Research Laboratory (BRL) and the Human Genome Sequencing Center (HGSC) at Baylor College of Medicine. She supervises and trains data analysts and researchers in methods for statistical analysis and contributes to the preparation of grants and manuscripts and is also responsible for continued evaluation, organization, and training of accessible bioinformatic tools as well as supervising IT support for the installation of software packages and the software licensing for scientific software for the Pathology Research Group at Texas Children's Hospital.

Her expertize in data analysis includes:

  1. Microarray
  2. QtPCR
  3. CGH arrays
  4. MiRNA clinical data
  5. Metagenomics
  6. Metadata
  7. Nextgen sequence data analysis

Data Analysis tools and bioinformatics packages used include:

  1. R Statistical programming
  2. Bioconductor packages
  3. Integrated Genome Toolset (BCM-BRL)
  4. Agilent Genespring GX and Genomics Workbench
  5. BRB Array Tools
  6. Ingenuity Pathways Analysis
  7. Nquery
  8. SPSS

Education

  • Ph.D. in Department of Biochemistry & Biophysics (Texas A&M University) 1995-2002
  • Bachelor of Arts & Chemistry, with honors (Florida Atlantic University, Boca Raton, FL) 1981-1984

Publications

  • Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Finegold MJ, Petrosino JF, Conner ME, Versalovic J. (2011) Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. Gastroenterology. Submitted
  • GA Preidis, DM Saulnier, SE Blutt, T-A Mistretta, KP Riehle, AM Major, SF Venable, JP Barrish, MJ Finegold, JF Petrosino, RL Guerrant, ME Conner, J Versalovic (2011) Host response to probiotics determined by nutritional status of rotavirus-infected mice. Journal of Pediatric Gastroenterology and Nutrition. Submitted
  • KP Riehle, C Coarfa, A Jackson, J Ma, A Tandon, S Paithankar, S Raghuraman, T-A Mistretta, DM Saulnier, S Raza, A Diaz, R Shulman, K Aagaard-Tillery, J Versalovic, A Milosavljevic (2011) The Genboree Microbiome Toolset and the Analysis of 16S rRNA Microbial Sequences. 8th Annual Biotechnology and Bioinformatics Symposium. BMC Bioinformatics. Submitted
  • Saulnier DM, Riehle K, Mistretta TA, et al. (2011) Gastrointestinal Microbiome Signatures Of Pediatric Patients With Irritable Bowel Syndrome. Gastroenterology. (Online ahead of publication: 2011 Jul 7).
  • Saulnier DM, Santos F, Roos S, Mistretta T-A, Spinler JK, et al. (2011) Exploring Metabolic Pathway Reconstruction and Genome-Wide Expression Profiling in Lactobacillus reuteri to Define Functional Probiotic Features. PLoS ONE 6(4): e18783. doi:10.1371/journal.pone.0018783
  • Mohan Venkatesh, Rong Liang, Toni-Ann Mistretta, James Versalovic (2011) Genome Wide Transcriptional Response of Staphylococcus epidermidis to C. albicans in Mixed Species Environments: Up Regulation of Virulence and Quorum Sensing. (In Preparation)
  • Mendez-Figueroa, M.D., Chunliu Su, M.D., Robert H. Lane, M.D., Toni-Ann Mistretta, Ph.D., Kjersti Aargaard-Tillery, M.D., Ph.D. (2011 ) Dysregulation of Npas2 leads to altered peripheral metabolic pathways in a murine knockout model.( In Preparation)
  • Lauren Becnel Boyd, Jae-Wook Jeong, Kevin Y. Lee, Heather L. Franco, Edward S. Chen, Apollo McOwiti, Toni-Ann Mistretta, David Steffen, and Franco J. DeMayo (2011) The Endometrium Database Resource, a multi-organism system for studies of Uterus-associated Genes. (Submitted).
  • Dolores López-Terrada, Preethi Guanaratne, Adekunle M. Adesina, Joseph Pulliam, David M Hoang, Yummy Nguyen, strong>Toni-Ann Mistretta, Judy Margolin, Milton Finegold (2008) Histologic subtypes of hepatoblastoma are characterized by differential canonical WNT and Notch pathway activation in arrested DLK+ precursors.Hum Pathol. doi:10.1016/j.humpath.2008.07.022
  • Mistretta, T., Guarino L.A. (2005) Transcriptional Activity of Baculovirus Very Late Factor 1. Journal of Virology (79) 1958-1960
  • Guarino, L.A., Mistretta, T., Dong, W. (2002) DNA binding activity of the baculovirus late expression factor PP31. Virus Research 90(1-2):187-95.
  • Guarino, L.A., Mistretta, T., Dong, W. (2002) Lef-12 is not involved in viral replication. Journal of Virology (76): 12032-43.
  • Fernandes D.J., Smith-Nanni, C., Paff, M.T., Neff, (Mistretta) T.A. (1988) Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells. Cancer Research. 48(7):1850-5.

Abstracts

  • Kevin Riehle, Delphine Saulnier, Cristian Coarfa, Toni-Ann Mistretta, Maria-Alejandra Diaz, Sabeen Raza, Robert J. Shulman, Aleksandar Milosavljevic, James Versalovic (March, 2011) Comparative Taxonomic and Platform Tools Development: Application in the Pediatric IBS Microbiome Study. HMP Meeting, Houston, TX
  • Toni-Ann Mistretta, Delphine Saulnier, Kevin Riehle, Sabeen Raza, Cristian Coarfa, Maria-Alejandra Diaz, Robert J. Shulman, Aleksandar Milosavljevic, James Versalovic (March, 2011) Microbial Signatures Present In Gut Microbiomes of Pediatric Irritable Bowel Syndrome . IHMC, Vancouver, CA
  • Kevin Riehle, Delphine Saulnier, Cristian Coarfa, Toni-Ann Mistretta, Maria-Alejandra Diaz, Sabeen Raza, Robert J. Shulman, Aleksandar Milosavljevic, James Versalovic (January, 2010) Comparative Taxonomic and Platform Tools Development: Application in the Pediatric IBS Microbiome Study. HMP Meeting, Houston, TX
  • Toni-Ann Mistretta, Kevin Riehle, Delphine Saulnier, Maria-Alejandra Diaz, Sabeen Raza, Erica Baimbridge, Cristian Coarfa, Debasmita Mandal, Susan Lynch, Xiang Qin, Aleksandar Milosavljevic, Joseph Petrosino, Sarah Highlander, Richard Gibbs, Robert J. Shulman, James Versalovic (August 31- Sept 2, 2010) Pediatric Microbiomes Associated with Subtypes of Irritable Bowel Syndrome Human Microbiome Research Conference, St. Louis, MO
  • Delphine Saulnier, Kevin Riehle, Toni-Ann Mistretta, Maria-Alejandra Diaz, Sabeen Raza, Erica Baimbridge, Cristian Coarfa, Debasmita Mandal, Susan Lynch, Xiang Qin, Aleksandar Milosavljevic, Joseph Petrosino, Sarah Highlander, Richard Gibbs, Robert J. Shulman, James Versalovic (August 31- Sept 2, 2010) Microbial Signatures Present in Microbiomes of Pediatric Irritable Bowel Syndrome. Human Microbiome Research Conference, St. Louis, MO
  • Mistretta, T and Guarino, L.A. (1998-2001) Annual Poster Session. Texas A&M University, Department of Biochemistry & Biophysics.
  • Mistretta, T and Guarino, L.A. (2001) The Role Of Very Late Factor-1 (VLF-1) in the baculovirus life cycle. 2001 Texas A&M University System Agriculture Program Conference Student Poster Competition, Texas A&M University.
  • Mistretta, T and Guarino, L.A. (1999) The Role of Very Late Factor-1 (VLF-1) in Very Late Gene Expression of Autographa californica Nucleopolyhedrosis Virus. XV Lost Pines Conference, Science Park, Research Division, Smithville, TX.
  • Caldwell, M. C., Park, Y., Mistretta, T.-A., and Datta, S. (1996).The CNS Cell cycle regulator anachronism also functions during PNS development. Keystone Symposium: The Cell Cycle, Taos, NM.
  • Caldwell, M. C., Park, Y., Mistretta, T.-A., and Datta, S. (1996).The CNS Cell cycle regulator anachronism also functions during PNS development. Keystone Symposium: The Cell Cycle, Taos, NM.

Presentations

Mistretta, T and Guarino, L.A. (2000) Investigation of Promoter Binding and Transcription Activity of Autographa californica nucleopolyhedrosis virus Very Late Factor 1. 19th Annual Meeting of American Society for Virology, Fort Collins, CO


Professional Memberships


Awards and Fellowships

  • Recognition Award Biochemistry Graduate Student Association
  • Regent's Fellowship Texas A&M University, Department of Biochemistry & Biophysics
  • Dean's Fellowship Bowman Gray School of Medicine, Winston-Salem, NC
  • Rosamond & Carey Jackson Memorial Award for excellence in writing and academic achievement, Florida Atlantic University, Boca Raton, FL
  • Dean's List, President's Honor List Florida Atlantic University
  • Renee Diane Neal Outstanding Sophomore Scholarship, Palm Beach JC, Lake Worth, FL

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