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Path-Immuno - James Versalovic Lab

Houston, Texas

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Path-Immuno - James Versalovic Lab
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Immunomodulins Identified in Lactobacillus reuteri

Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling.


Histamine produced by L. reuteri is not modified



Histamine Concentration Correlates with TNF Inhibitory Activity

Histamine quantified using Triple Quadrupole MS

Histamine Produced by L. reuteri Inhibits the ERK Signaling Pathway


Histamine Produced by L. reuteri Inhibits TNF via the H2 Receptor



Histamine Produced by L. reuteri Inhibits TNF by Interacting with the H2 Receptor and inhibiting ERK Signaling


Publication:

Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, Britton RA, Kalkum M, Versalovic J. Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling. PLoS One. 2012;7(2):e31951. Epub 2012 Feb 22. PubMed PMID: 22384111; PubMed Central PMCID: PMC3285189. Article

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