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Pathology & Immunology

Houston, Texas

Pathology and Immunology
Pathology & Immunology
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Angshumoy Roy, M.D., Ph.D.

Assistant Professor
Departments of Pathology & Immunology and Pediatrics

Principal Investigator
Investigative and Genomic Pathology
Texas Children's Hospital
1102 Bates Avenue, Suite FC955.07
Houston, TX 77030


  • MBBS, Calcutta Medical College, University of Calcutta, India
  • Phd, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX


  • Anatomic and Clinical Pathology, Baylor College of Medicine, Houston, TX


  • Molecular Genetic Pathology


  • Molecular Genetic Pathology, Baylor College of Medicine, Houston, TX

Board Certification

  • American Board of Pathology, AP/CP

Research Interests

  • Investigating the patterns of global DNA methylation alterations and the effects on the pathobiology of embryonal cancers. A related research interest is in studying genomic alterations, including structural variations and copy-number changes in these tumors.

Honors and Awards

  • Society for Pediatric Pathology 2012 `Young Investigator Award', 2012
  • Hans Popper Hepatopathology Society 2012 Resident-in-Training Award for Best Abstract at the 2012 USCAP meeting, Vancouver, BC, 2012
  • H. Stephen Gallager Resident Award from the Houston Society of Clinical Pathologists, 2012
  • Roche Diagnostics Inc. & College of American Pathologists Foundation Advanced Training Grant Award in Pharmacogenetics(work completed at University of California, Irvine), 2010
  • Chief Resident title, Anatomic and Clinical Pathology, Baylor College of Medicine, 2009-2010
  • Milton J. Finegold Graduate Student Achievement Award, Department of Pathology, Baylor College of Medicine, 2007
  • National Institutes of Health Travel Award for best abstract (from Andrology Society of America), Testis Workshop, Phoenix, AZ, 2003
  • Junior Research Fellowship at National Centre for Biological Sciences, Bangalore, India, 2000-2001


  • Chavan R, Patel KU, Roy A, Thompson P, Chintagumpala M, Goss J, Nuchtern J, Finegold MJ, Parsons D, Lopez-Terrada, DH. Mutations of PTCH1, MLL2, and MLL3 are not frequent events in Hepatoblastoma. Pediatr Blood Cancer. 2012 Jun;58(6):1006-7.
  • Magoulas P, El-Hattab A, Roy A, Bali D, Finegold MJ, Craigen WJ. Diffuse reticuloendothelial system involvement in type IV glycogen storage disease with a novel GBE1 mutation: A case report and review. Hum Pathol. 2012 Jun;43(6):943-51.
  • Yatsenko AN, O'Neil DS, Roy A, Arias-Mendoza PA, Chen R, Murthy LJ, Lamb DJ, Matzuk MM. Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men. Mol Hum Reprod. 2012 Jan;18(1):14-21.
  • Hanchard NA, Shchelochkov OA, Roy A, Wiszniewska J, Wang J, Popek EJ, Karpen S, Wong LJ, Scaglia F. Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis. Mol Genet Metab. 2011 Jul;103(3):262-7.
  • Roy A and Matzuk MM. Reproductive tract function and dysfunction in women. Nat Rev Endocrinol. 2011 May 24;7(9):517-25.
  • Marino-Enriquez A, Wang, WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin, CM, Hornick JL. Epithelioid Inflammatory Myofibroblastic Sarcoma: An Aggressive Intra-abdominal Variant of Inflammatory Myofibroblastic Tumor With Nuclear Membrane or Perinuclear ALK. Am J Surg Pathol. 2011 Jan;35(1):135-44.
  • Roy A and Finegold MJ. Hepatic Neoplasia and Metabolic Diseases in Children. Clin Liver Dis. 2010 Nov;14(4):731-46.
  • Roy A and Finegold MJ. Biopsy Diagnosis of Inherited Liver Disease. Surg Pathol Clin. 3(2010) 743-68.
  • Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk, MM. GASZ is Essential for Male Meiosis and Suppression of Retrotransposon Synthesis in the Male Germline. PLoS Genet. 2009 Sep;5(9).
  • Roy A, Lin YN, Agno JE, Demayo FJ, Matzuk MM. Tektin 3 is required for progressive sperm motility in mice. Mol Reprod Dev. 2009 May;76(5):453-9.
  • Lin YN, Roy A, Yan W, Burns KH, Matzuk MM. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Mol Cell Biol 2007;27(19):6794-805.
  • Roy A, Lin YN, Agno JE, DeMayo FJ, Matzuk MM. Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. Faseb J 2007. Apr;21(4):1013-25.
  • Roy A, Matzuk MM. Society for Reproductive Biology Founders' Lecture 2007. Insights into germ cell biology: from the bench to the clinic. Reprod Fert Develop 2007;19(7):783-91.
  • Roy A, Lin YN, Matzuk MM. Shaping the sperm head: an ER enzyme leaves its mark. J Clin Invest 2006;116(11).
  • Roy A, Matzuk MM. Deconstructing mammalian reproduction: using knockouts to define fertility pathways. Reproduction 2006;131(2):207-19.
  • Yatsenko AN*, Roy A*, Chen R, Murthy LJ, Lamb DJ, Matzuk MM. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Hum Mol Genet 2006;15(23):3411-9.*equal contributors
  • Sen K, Roy A. Management of neonatal purpura fulminans with severe protein C deficiency. Indian Pediatr 2006;43(6):542-5.
  • Roy A, Yan W, Burns KH, Matzuk MM. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. Mol Reprod Dev 2004;67(3):295-302.

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