Roger D. Rossen, M.D. - Faculty
Professor, Department of Pathology & Immunology
M.D., Case Western Reserve University
Postdoctoral, National Institutes of Health, Columbia University
Research Interests: Inflammation in Response to Cardiac Injury
Our group investigates the mechanisms mobilized in response to cardiac tissue injury caused by virus infections and by reduced blood supply, as may occur following a coronary artery occlusion or heart attack. When cardiac tissues are damaged, the contents of the cells that are released eventually make their way into the circulation. Mitochondria are among the intracellular organelles released by damaged heart cells. Because these display structures that are also found on bacteria, mitochondria released from inside the cell trigger inflammatory responses that are similar to those triggered by bacterial infections. Consequently, injury to the heart triggers an intense infiltration of white blood cells. These infiltrating white blood cells release enzymes and oxidative radicals that injure healthy cells that surround the area of injury. The white blood cells that accumulate in damaged heart tissues also provide benefits. They remove damaged cardiac cells and promote healing. One of the aims of our research is to discover treatments that modulate this response in ways that maximize tissue repair and minimize collateral damage. Continued stimulation of an inflammatory response, as occurs when the heart is infected with cardiotropic viruses, can stimulate immune responses directed against cardiac tissue antigens. The resulting autoimmune response may cause chronic disabling heart disease.
Rossen RD. and Mann DL. (1995). Myocardial Inflammation, a Chapter in Clinical Immunology,ed. by R. R. Rich, CV Mosby and Co.
Trial J. Birdsall HH. Hallum JA. Crane ML. Rodriguez-Barradas M. deJong A. Krishnan B. Lacke CE Figdor CG. Rossen RD. Phenotypic and functional changes in peripheral blood monocytes during progression of HIV infection: Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1 encoded proteins on monocyte phagocytic function, oxidative burst, transendothelial migration and cell surface phenotype., J. Clin. Invest.95: 1690-1701, 1995.
Kumar AG. Ballantyne CM. Michael LH. Kukielka GL. Youker KA. Lindsey ML. Hawkins HK. Birdsall HH. MacKay CR. LaRosa GJ. Rossen RD. Smith CW. Entman ML. Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium. Circulation. 95(3):693-700, 1997.
Youker KA. Birdsall HH. Frangogiannis NG. Kumar AG. Lindsey ML. Ballantyne CM. Rossen RD. Entman ML. Phagocytes in ischemic injury. In Phagocytes: Biology, Physiology, Pathology, and Pharmacotherapeutics. Annuals of the New York Academy of Sciences. 832:243-265, 1997.
Birdsall HH. Trial J. Lin HJ. Green DM. Sorrentino GW. Siwak EB. de Jong AL. Rossen RD. Transendothelial migration of lymphocytes from HIV-1 infected donors: A mechanism for extravascular dissemination of HIV-1. Journal of Immunology. 158(2):5968-5977, 1997.
Frangogiannis NG. Youker KA. Rossen RD. Gwechenberger M. Lindsey M. Mendoza M. Michael LH. Ballantyne CM. Smith CW. Entman ML. Cytokines and the microcirculation in ischemia and reperfusion. Journal Molecular Cell Cardiology 12:2567-2776, 1998.
Trial J. Baughn RE. Wygant JN. McIntyre BW. Birdsall HH. Youker KA. Evans A. Entman ML. Rossen RD. Fibronectin fragments modulate monocyte VLA-5 expression and monocyte migration. Journal of Clinical Investigation. 104(4):419-430, 1999.
Lindsey M. Wedin K. Brown MD. Keller C. Evans AJ. Smolen J. Burns AR. Rossen RD. Michael LH. Entman ML. Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia-reperfusion. Circulation 103:2181-2187, 2001.
Rossen RD. Mann DL. Myocardial Inflammation, Chapter 80, in Clinical Immunology: Principles and Practice. Ed. by Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Brian L. Kotzin, and Harry W. Schroeder, Jr. 2nd Edition Mosby London, pp. 80.1-80.15, 2001.
Birdsall HH. Siwak EB, Trial J. Rodriguez-Barradas M. White AC Jr. Wietgrefe S. Rossen RD. Transendothelial migration of leukocytes carrying infectious HIV-1: An indicator of adverse prognosis. AIDS 16(1):5-12, 2002.
Tran T. Rossen RD. Mann DL. Recent insights into the Molecular Pathophysiology of Viral Myocarditis, in "Principles of Molecular Cardiology" ed. Patterson C. in press.
For a complete list of Dr. Rossen's publications, visit PubMed.
Department of Pathology & Immunology
Baylor College of Medicine
One Baylor Plaza, BCM245
Houston, Texas 77030 Phone: 713-794-7772