Jin Wang, Ph.D. - Faculty
Associate Professor, Department of Pathology & Immunology
Ph.D., University of Southern California
Postdoctoral Fellow, NIH
Research Interests: Molecular regulation of immune responses by apoptosis and autophagy
We are interested in understanding the mechanisms for the maintenance of immune tolerance and development of autoimmunity.
Apoptosis pathways in lymphocytes - We are employing the conditional knockout approaches to delete important apoptotic genes in lymphocytes. This will enable us to dissect the functions of these apoptotic molecules in regulating lymphocyte functions in defined cell lineages at different stages of development.
Regulation of immune tolerance by apoptosis in dendritic cells- We are studying how apoptosis regulates the functions of dendritic cells, the most potent antigen presenting cells. We are generating conditional deletion of essential apoptosis molecules in dendritic cells. We will characterize how defective apoptosis in dendritic cells affects lymphocyte homeostasis and self-tolerance.
Regulation of the survival and functions of different immune cell types by autophagy - Autophagy may help to protect cell survival and proliferation by removing damaged mitochondria and other organelles. However, excessive clearance of mitochondria might contribute to cell death. We are studying the mechanisms for regulating mitochondrial quality control by autophagy in lymphocytes and dendritic cells, and how autophagy might affect immune responses by regulating the survival and functions of different cell types in the immune system.
We welcome applications for postdoctoral positions (email@example.com).
- Chen, M., Wang, Y.H., Wang, Y., Huang, L., Sandoval, H., Liu, Y.J., and Wang, J. (2006) Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311:1160-1164.
- Chen, M., Huang, L., Shabier, Z. and Wang, J. (2007) Regulation of the lifespan in dendritic cell subsets. Mol. Immunology 44:2558-2265.
- Chen, M., Huang, L. and Wang, J. (2007) Deficiency of Bim in dendritic cells contributes to over-activation of lymphocytes and autoimmunity. Blood 109:4360-4367.
- Chen, M., Guerrero, A.D., Huang, L., Shabier, Z., Pan, M., Tan, T.-H. and Wang, J. (2007) Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic Bcl-2 family members. J. Biol. Chem. 282:33888-33895.
- Guerrero, A.D., Chen, M., and Wang, J. (2008) Delineation of the caspase-9 signaling cascade. Apoptosis 13:177-186.
- Sandoval, H., Thiagarajan, P., Dasgupta, S.K., Schumacher, A., Prchal, J.T., Chen, M., and Wang, J. (2008) Essential roles for Nix in autophagic maturation of erythroid cells. Nature 454:232-235.
- Chen, M., Sandoval, H. and Wang, J. (2008) Selective mitochondrial autophagy during erythroid maturation. Autophagy 4:926-928.
- Chen, M. and Wang, J. (2010) Programmed cell death of dendritic cells in immune regulation. Immunological Review 236:11-27.
For a complete list of Dr. Wang's publications, visit PubMed.
Contact Information:Dr. Jin Wang
Department of Immunology
Baylor College of Medicine
One Baylor Plaza, BCM245
Houston, Texas 77030 Telephone: 713-798-6193